FGF7

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.[5][6][7]

FGF7
Identifiers
Aliases	FGF7, HBGF-7, KGF, fibroblast growth factor 7
External IDs	OMIM: 148180 MGI: 95521 HomoloGene: 7316 GeneCards: FGF7
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 49,423,178 bp[1] End 49,488,775 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 126,034,658 bp[2] End 126,091,185 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • heparin binding • fibroblast growth factor receptor binding • GO:0001948 protein binding • chemoattractant activity • growth factor activity • 1-phosphatidylinositol-3-kinase activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity Cellular component • Golgi apparatus • extracellular region Biological process • actin cytoskeleton reorganization • mesenchymal cell proliferation • positive regulation of keratinocyte proliferation • positive regulation of epithelial cell proliferation involved in lung morphogenesis • secretion by lung epithelial cell involved in lung growth • positive regulation of epithelial cell proliferation • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • MAPK cascade • positive regulation of transcription, DNA-templated • fibroblast growth factor receptor signaling pathway • positive regulation of keratinocyte migration • protein localization to cell surface • response to wounding • positive regulation of cell proliferation • epidermis development • positive regulation of peptidyl-tyrosine phosphorylation • hair follicle morphogenesis • positive chemotaxis • positive regulation of cell division • signal transduction • branching involved in salivary gland morphogenesis • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • regulation of receptor activity • positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2252	14178
Ensembl	ENSG00000140285	ENSMUSG00000027208
UniProt	P21781	P36363
RefSeq (mRNA)	NM_002009	NM_008008
RefSeq (protein)	NP_002000	NP_032034
Location (UCSC)	Chr 15: 49.42 – 49.49 Mb	Chr 2: 126.03 – 126.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.[7]

Interactions

FGF7 has been shown to interact with Perlecan.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000140285 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027208 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I (Mar 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mammalian Genome. 6 (3): 196–7. doi:10.1007/BF00293012. PMID 7749227.
6. Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (Oct 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9287–91. doi:10.1073/pnas.89.19.9287. PMC 50111. PMID 1409637.
7. "Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)".
8. Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.

Further reading

• Beer HD, Gassmann MG, Munz B, Steiling H, Engelhardt F, Bleuel K, Werner S (Dec 2000). "Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair". The Journal of Investigative Dermatology. Symposium Proceedings. 5 (1): 34–9. doi:10.1046/j.1087-0024.2000.00009.x. PMID 11147673.
• Ware LB, Matthay MA (May 2002). "Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair". American Journal of Physiology. Lung Cellular and Molecular Physiology. 282 (5): L924–40. doi:10.1152/ajplung.00439.2001. PMID 11943656.
• Finch PW, Rubin JS (2004). "Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair". Advances in Cancer Research. 91: 69–136. doi:10.1016/S0065-230X(04)91003-2. ISBN 978-0-12-006691-9. PMID 15327889. Cite journal requires |journal= (help)
• Ishibashi T, Bottaro DP, Chan A, Miki T, Aaronson SA (Dec 1992). "Expression cloning of a human dual-specificity phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 89 (24): 12170–4. doi:10.1073/pnas.89.24.12170. PMC 50720. PMID 1281549.
• Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG, Rubin JS (1992). "Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity". Annals of the New York Academy of Sciences. 638: 62–77. doi:10.1111/j.1749-6632.1991.tb49018.x. PMID 1664700.
• Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA (Aug 1989). "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth". Science. 245 (4919): 752–5. doi:10.1126/science.2475908. PMID 2475908.
• Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA (Feb 1989). "Purification and characterization of a newly identified growth factor specific for epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 802–6. doi:10.1073/pnas.86.3.802. PMC 286565. PMID 2915979.
• Ron D, Reich R, Chedid M, Lengel C, Cohen OE, Chan AM, Neufeld G, Miki T, Tronick SR (Mar 1993). "Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor". The Journal of Biological Chemistry. 268 (8): 5388–94. PMID 7680645.
• Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL (Aug 1993). "Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy". Molecular and Cellular Biology. 13 (8): 4513–22. doi:10.1128/MCB.13.8.4513. PMC 360063. PMID 7687739.
• Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT (Nov 1994). "The function of KGF in morphogenesis of epithelium and reepithelialization of wounds". Science. 266 (5186): 819–22. doi:10.1126/science.7973639. PMID 7973639.
• Wilson SE, Walker JW, Chwang EL, He YG (Jul 1993). "Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea". Investigative Ophthalmology & Visual Science. 34 (8): 2544–61. PMID 8392040.
• Guo L, Degenstein L, Fuchs E (Jan 1996). "Keratinocyte growth factor is required for hair development but not for wound healing". Genes & Development. 10 (2): 165–75. doi:10.1101/gad.10.2.165. PMID 8566750.
• Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (Jun 1996). "Receptor specificity of the fibroblast growth factor family". The Journal of Biological Chemistry. 271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID 8663044.
• Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, Tanswell AK (Oct 1996). "Keratinocyte growth factor and its receptor are involved in regulating early lung branching". Development. 122 (10): 3107–15. PMID 8898224.
• Zimonjic DB, Kelley MJ, Rubin JS, Aaronson SA, Popescu NC (Oct 1997). "Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans". Proceedings of the National Academy of Sciences of the United States of America. 94 (21): 11461–5. doi:10.1073/pnas.94.21.11461. PMC 23506. PMID 9326632.
• Winkles JA, Alberts GF, Chedid M, Taylor WG, DeMartino S, Rubin JS (Dec 1997). "Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries". Journal of Cellular Physiology. 173 (3): 380–6. doi:10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G. PMID 9369951.
• Ishibashi T, Tanaka T, Nibu K, Ishimoto S, Kaga K (Oct 1998). "Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps". The Annals of Otology, Rhinology, and Laryngology. 107 (10 Pt 1): 885–90. doi:10.1177/000348949810701013. PMID 9794620.
• Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.