GFRA3

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.[5][6]

GFRA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GH0
Identifiers
Aliases	GFRA3, GDNFR3, GDNF family receptor alpha 3
External IDs	OMIM: 605710 MGI: 1201403 HomoloGene: 1146 GeneCards: GFRA3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 138,252,380 bp[1] End 138,274,621 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 34,689,898 bp[2] End 34,720,387 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • axon guidance receptor activity • Ras guanyl-nucleotide exchange factor activity • GO:0001948 protein binding • signaling receptor activity Cellular component • membrane • anchored component of membrane • external side of plasma membrane • extrinsic component of membrane • cell membrane • cytosol • receptor complex Biological process • neuron development • neuron migration • peripheral nervous system development • sympathetic nervous system development • signal transduction • nervous system development • MAPK cascade • axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2676	14587
Ensembl	ENSG00000146013	ENSMUSG00000024366
UniProt	O60609	O35118
RefSeq (mRNA)	NM_001496	NM_010280
RefSeq (protein)	NP_001487	NP_034410
Location (UCSC)	Chr 5: 138.25 – 138.27 Mb	Chr 18: 34.69 – 34.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.[6]

See also

• GFRα

References

1. GRCh38: Ensembl release 89: ENSG00000146013 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024366 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
6. "Entrez Gene: GFRA3 GDNF family receptor alpha 3".

Further reading

• Wang X, Baloh RH, Milbrandt J, Garcia KC (Jun 2006). "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors". Structure. 14 (6): 1083–92. doi:10.1016/j.str.2006.05.010. PMID 16765900.
• Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. Check date values in: |year= / |date= mismatch (help)
• Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C (Apr 2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma". Oncogene. 20 (17): 2161–70. doi:10.1038/sj.onc.1204289. PMID 11360200.
• Onochie CI, Korngut LM, Vanhorne JB, Myers SM, Michaud D, Mulligan LM (Sep 2000). "Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease". Journal of Medical Genetics. 37 (9): 674–9. doi:10.1136/jmg.37.9.674. PMC 1734691. PMID 10978357.
• Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM, Milbrandt J (Dec 1998). "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex". Neuron. 21 (6): 1291–302. doi:10.1016/S0896-6273(00)80649-2. PMID 9883723. Check date values in: |year= / |date= mismatch (help)
• Baloh RH, Gorodinsky A, Golden JP, Tansey MG, Keck CL, Popescu NC, Johnson EM, Milbrandt J (May 1998). "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family". Proceedings of the National Academy of Sciences of the United States of America. 95 (10): 5801–6. doi:10.1073/pnas.95.10.5801. PMC 20460. PMID 9576965.
• Masure S, Cik M, Pangalos MN, Bonaventure P, Verhasselt P, Lesage AS, Leysen JE, Gordon RD (Feb 1998). "Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)". European Journal of Biochemistry / FEBS. 251 (3): 622–30. doi:10.1046/j.1432-1327.1998.2510622.x. PMID 9490034.
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101. Check date values in: |year= / |date= mismatch (help)