Ampicillin/flucloxacillin

Ampicillin/flucloxacillin
Combination of
Ampicillin	Moderate-spectrum penicillin
Flucloxacillin	Antistaphylococcal penicillin
Clinical data
Routes of; administration	Oral, intravenous
ATC code	J01CR50 (WHO) ;
Identifiers
CAS Number	56749-84-9;
ChemSpider	21106281 ;
UNII	7C782967RD; 43B2M34G2V ;
CompTox Dashboard (EPA)	DTXSID90894834 ;
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Ampicillin/flucloxacillin (INNs) or co-fluampicil (BAN) is a combination drug of the two β-lactam antibiotics ampicillin and flucloxacillin, sold under the tradenames Magnapen[1] and Infectrin.

Indication

Ampicillin is a moderate-spectrum penicillin antibiotic with good cover against group A streptococcal infection, whilst flucloxacillin is a narrow-spectrum antibiotic with cover against Staphylococcus aureus. The combination covers the two most likely bacteria in cellulitis infections in the arm or leg.

Formulations

Capsules contain 250 mg of each component, the syrup 125/125 mg per spoon, and the powder for reconstruction for intravenous injection 250/250 mg.

Side effects and contraindications

Side effects are the same as per the individual components, with stomach or bowel upset from the flucloxacillin being the most common. Both parts are members of the penicillin family of antibiotics, so should not be taken by patients allergic to penicillin. See flucloxacillin for additional contraindications.

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References

Lloyd-Williams J, Robinson AT (1980). "The treatment of infections in general practice with magnapen: a multicentre trial". The Journal of International Medical Research. 8 (6): 417–23. doi:10.1177/030006058000800610. PMID 7439518.

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[1] Lloyd-Williams J, Robinson AT (1980). "The treatment of infections in general practice with magnapen: a multicentre trial". The Journal of International Medical Research. 8 (6): 417–23. doi:10.1177/030006058000800610. PMID 7439518.