Cefonicid
Cefonicide (or cefonicid) is a cephalosporin antibiotic.[1]
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| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| MedlinePlus | a601206 |
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| Formula | C18H18N6O8S3 |
| Molar mass | 542.56 g·mol−1 |
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It has a density of 1.92g/cm3.
Synthesis
Injectable semi-synthetic cephalosporin antibiotic related to cefamandole, q.v.
Cefonicid is synthesized conveniently by nucleophilic displacement of the 3-acetoxy moiety of 1 with the appropriately substituted tetrazole thiole 2. The mandelic acid amide C-7 side chain is reminiscent of cefamandole.
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See also
References
- Saltiel E, Brogden RN (September 1986). "Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use". Drugs. 32 (3): 222–59. doi:10.2165/00003495-198632030-00002. PMID 3530703.
- D. A. Berges, DE 2611270; idem, U.S. Patent 4,048,311 (1976, 1977 both to Smith Kline).
- U.S. Patent 4,093,723, U.S. Patent 4,159,373 (1978, 1979 both to Smith Kline).
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