P2RY4

P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.[5][6]

P2RY4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B6Q
Identifiers
Aliases	P2RY4, NRU, P2P, P2Y4, UNR, pyrimidinergic receptor P2Y4
External IDs	OMIM: 300038 MGI: 1926594 HomoloGene: 20568 GeneCards: P2RY4
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 70,258,170 bp[1] End 70,259,764 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C3 Start 100,590,154 bp[2] End 100,594,869 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled purinergic nucleotide receptor activity • UTP-activated nucleotide receptor activity • ATP binding • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • basolateral plasma membrane • integral component of plasma membrane • apical plasma membrane • membrane • glutamatergic synapse • integral component of presynaptic active zone membrane Biological process • positive regulation of cytosolic calcium ion concentration • phospholipase C-activating G-protein coupled receptor signaling pathway • transepithelial chloride transport • signal transduction • G-protein coupled purinergic nucleotide receptor signaling pathway • cellular response to prostaglandin E stimulus • G-protein coupled receptor signaling pathway • cellular response to ATP • regulation of presynaptic cytosolic calcium ion concentration • regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5030	57385
Ensembl	ENSG00000186912	ENSMUSG00000044359
UniProt	P51582	Q9JJS7
RefSeq (mRNA)	NM_002565	NM_020621
RefSeq (protein)	NP_002556	NP_065646
Location (UCSC)	Chr X: 70.26 – 70.26 Mb	Chr X: 100.59 – 100.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The product of this gene, P2Y₄, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.[6]

See also

• P2Y receptor

References

1. GRCh38: Ensembl release 89: ENSG00000186912 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044359 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Communi D, Pirotton S, Parmentier M, Boeynaems JM (Feb 1996). "Cloning and functional expression of a human uridine nucleotide receptor". J Biol Chem. 270 (52): 30849–52. doi:10.1074/jbc.270.52.30849. PMID 8537336.
6. "Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4".

Further reading

• Nguyen T, Erb L, Weisman GA, et al. (1996). "Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene". J. Biol. Chem. 270 (52): 30845–8. doi:10.1074/jbc.270.52.30845. PMID 8537335.
• Stam NJ, Klomp J, Van de Heuvel N, Olijve W (1996). "Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor". FEBS Lett. 384 (3): 260–4. doi:10.1016/0014-5793(96)00321-3. PMID 8617367.
• Nicholas RA, Watt WC, Lazarowski ER, et al. (1996). "Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor". Mol. Pharmacol. 50 (2): 224–9. PMID 8700127.
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704.
• Jin J, Dasari VR, Sistare FD, Kunapuli SP (1998). "Distribution of P2Y receptor subtypes on haematopoietic cells". Br. J. Pharmacol. 123 (5): 789–94. doi:10.1038/sj.bjp.0701665. PMC 1565225. PMID 9535005.
• Brinson AE, Harden TK (2001). "Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor". J. Biol. Chem. 276 (15): 11939–48. doi:10.1074/jbc.M009909200. PMID 11114308.
• Suarez-Huerta N, Pouillon V, Boeynaems J, Robaye B (2001). "Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor". Eur. J. Pharmacol. 416 (3): 197–202. doi:10.1016/S0014-2999(01)00875-5. PMID 11290369.
• Moore DJ, Chambers JK, Wahlin JP, et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochim. Biophys. Acta. 1521 (1–3): 107–19. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642.
• Idzko M, Dichmann S, Ferrari D, et al. (2002). "Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors". Blood. 100 (3): 925–32. doi:10.1182/blood.V100.3.925. PMID 12130504.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors". J. Invest. Dermatol. 120 (3): 440–7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858.
• Kim SG, Soltysiak KA, Gao ZG, et al. (2003). "Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors". Biochem. Pharmacol. 65 (6): 923–31. doi:10.1016/S0006-2952(02)01614-3. PMC 3402349. PMID 12623123.
• Herold CL, Qi AD, Harden TK, Nicholas RA (2004). "Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop". J. Biol. Chem. 279 (12): 11456–64. doi:10.1074/jbc.M301734200. PMC 1821344. PMID 14670966.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cavaliere F, Nestola V, Amadio S, et al. (2005). "The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells". Neurobiol. Dis. 18 (1): 100–9. doi:10.1016/j.nbd.2004.09.001. PMID 15649700.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.

External links

• "P2Y Receptors: P2Y₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.