Latrophilin 2

Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.[5][6]

ADGRL2
Identifiers
AliasesADGRL2, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2
External IDsOMIM: 607018 MGI: 2139714 HomoloGene: 22712 GeneCards: ADGRL2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p31.1Start81,306,160 bp[1]
End81,992,436 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23266

99633

Ensembl

ENSG00000117114

ENSMUSG00000028184

UniProt

O95490

Q8JZZ7

RefSeq (mRNA)

NM_001081298

RefSeq (protein)

NP_001074767

Location (UCSC)Chr 1: 81.31 – 81.99 MbChr 3: 148.82 – 148.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.[6]

See also

  • Adhesion G protein-coupled receptors

References

  1. GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.
  6. "Entrez Gene: LPHN2 latrophilin 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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