FZD2

Frizzled-2 is a protein that in humans is encoded by the FZD2 gene.[5][6][7]

FZD2
Identifiers
Aliases	FZD2, Fz2, fz-2, fzE2, hFz2, frizzled class receptor 2, OMOD2
External IDs	OMIM: 600667 MGI: 1888513 HomoloGene: 20377 GeneCards: FZD2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 44,557,484 bp[1] End 44,561,262 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 102,604,396 bp[2] End 102,608,058 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • PDZ domain binding • signal transducer activity • GO:0001948 protein binding • transmembrane signaling receptor activity • G-protein coupled receptor activity • Wnt-protein binding • Wnt-activated receptor activity Cellular component • cytoplasm • clathrin-coated endocytic vesicle membrane • membrane • focal adhesion • cell membrane • integral component of membrane Biological process • G-protein coupled receptor signaling pathway • epithelial cell differentiation • muscular septum morphogenesis • ventricular septum morphogenesis • cell-cell signaling • membranous septum morphogenesis • outflow tract morphogenesis • positive regulation of sequence-specific DNA binding transcription factor activity • Wnt signaling pathway • planar cell polarity pathway involved in neural tube closure • positive regulation of transcription, DNA-templated • multicellular organism development • sensory perception of smell • cell surface receptor signaling pathway • inner ear receptor cell development • hard palate development • cochlea morphogenesis • neuron differentiation • canonical Wnt signaling pathway • signal transduction • beta-catenin destruction complex disassembly • Wnt signaling pathway, calcium modulating pathway • Wnt signaling pathway, planar cell polarity pathway • non-canonical Wnt signaling pathway • positive regulation of G-protein coupled receptor protein signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2535	57265
Ensembl	ENSG00000180340	ENSMUSG00000050288
UniProt	Q14332	Q9JIP6
RefSeq (mRNA)	NM_001466	NM_020510
RefSeq (protein)	NP_001457	NP_065256
Location (UCSC)	Chr 17: 44.56 – 44.56 Mb	Chr 11: 102.6 – 102.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.[7]

See also

• Frizzled

References

1. GRCh38: Ensembl release 89: ENSG00000180340 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050288 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics. 27 (2): 370–3. doi:10.1006/geno.1995.1060. PMID 7558010.
6. Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
7. "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)".

Further reading

• Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Oishi I, Suzuki H, Onishi N, et al. (2004). "The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway". Genes Cells. 8 (7): 645–54. doi:10.1046/j.1365-2443.2003.00662.x. PMID 12839624.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• "Frizzled Receptors: FZD₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.