Bombesin-like receptor 3

The bombesin receptor subtype 3 also known as BRS-3 or BB₃[5] is a protein which in humans is encoded by the BRS3 gene.[6][7]

BRS3
Identifiers
Aliases	BRS3, BB3, bombesin like receptor 3, BB3R, bombesin receptor subtype 3, BBR3
External IDs	OMIM: 300107 MGI: 1100501 HomoloGene: 1307 GeneCards: BRS3
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3 Start 136,487,947 bp[1] End 136,493,780 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A6 Start 57,043,074 bp[2] End 57,048,758 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • bombesin receptor activity • G-protein coupled peptide receptor activity • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • neuron projection • neuronal cell body • cell membrane • membrane • integral component of plasma membrane Biological process • regulation of blood pressure • G-protein coupled receptor signaling pathway • bombesin receptor signaling pathway • adult feeding behavior • signal transduction • glucose metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	680	12209
Ensembl	ENSG00000102239	ENSMUSG00000031130
UniProt	P32247	O54798
RefSeq (mRNA)	NM_001727	NM_009766
RefSeq (protein)	NP_001718	NP_033896
Location (UCSC)	Chr X: 136.49 – 136.49 Mb	Chr X: 57.04 – 57.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[7][8]

BB₃ is a G protein-coupled receptor.[6] BB₃ only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[6][9][10]

References

1. GRCh38: Ensembl release 89: ENSG00000102239 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031130 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Bombesin Receptors: BB₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
6. Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.
7. Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1–2): 165–72. doi:10.1016/S0006-8993(97)00380-6. PMID 9262170.
8. "Entrez Gene: BRS3 bombesin-like receptor 3".
9. Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors". J. Biol. Chem. 272 (41): 26062–26071. doi:10.1074/jbc.272.41.26062. PMID 9325344.
10. Jensen RT, Battey JF, Spindel ER, Benya RV (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states". Pharmacol. Rev. 60 (1): 1–42. doi:10.1124/pr.107.07108. PMC 2517428. PMID 18055507.

Further reading

• Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F (1994). "Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus" (PDF). FEBS Lett. 340 (3): 260–4. doi:10.1016/0014-5793(94)80150-9. PMID 8131855.
• Fathi Z, Corjay MH, Shapira H, et al. (1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.
• Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells". Peptides. 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519.
• Ohki-Hamazaki H, Watase K, Yamamoto K, et al. (1997). "Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity". Nature. 390 (6656): 165–9. doi:10.1038/36568. PMID 9367152.
• Ryan RR, Weber HC, Hou W, et al. (1998). "Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3". J. Biol. Chem. 273 (22): 13613–24. doi:10.1074/jbc.273.22.13613. PMID 9593699.
• Liu J, Lao ZJ, Zhang J, et al. (2002). "Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)". Biochemistry. 41 (28): 8954–60. doi:10.1021/bi0202777. PMID 12102638.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Hou X, Wei L, Harada A, Tatamoto K (2007). "Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells". Lung Cancer. 54 (2): 143–8. doi:10.1016/j.lungcan.2006.08.005. PMID 16979789.
• Tan YR, Qin XQ, Xiang Y, et al. (2007). "PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells". Biochem. J. 405 (1): 131–7. doi:10.1042/BJ20061754. PMC 1925247. PMID 17355223.

External links

• "Bombesin Receptors: BB₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• bombesin+receptor+subtype+3 at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human BRS3 genome location and BRS3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.