Neuromedin U receptor 2

Neuromedin-U receptor 2 is a protein that in humans is encoded by the NMUR2 gene.[5][6][7]

NMUR2
Identifiers
Aliases	NMUR2, FM-4, FM4, NMU-R2, NMU2R, TGR-1, TGR1, Neuromedin U receptor 2
External IDs	OMIM: 605108 MGI: 2441765 HomoloGene: 49618 GeneCards: NMUR2
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 152,391,532 bp[1] End 152,433,368 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 56,024,987 bp[2] End 56,041,010 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • signal transducer activity • neuromedin U binding • neuropeptide receptor activity • neuromedin U receptor activity • intracellular calcium activated chloride channel activity • GTP binding • G-protein coupled receptor activity Cellular component • integral component of membrane • membrane • cell membrane • intracellular Biological process • reduction of food intake in response to dietary excess • calcium ion transport • phospholipase C-activating G-protein coupled receptor signaling pathway • activation of phospholipase A2 activity by calcium-mediated signaling • feeding behavior • inositol phosphate-mediated signaling • regulation of smooth muscle contraction • arachidonic acid secretion • positive regulation of cytosolic calcium ion concentration • cell-cell signaling • response to pain • calcium-mediated signaling • signal transduction • personal grooming • central nervous system development • G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • ion transmembrane transport • regulation of sensory perception of pain Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56923	216749
Ensembl	ENSG00000132911	ENSMUSG00000037393
UniProt	Q9GZQ4	Q8BZ39
RefSeq (mRNA)	NM_020167	NM_153079
RefSeq (protein)	NP_064552	NP_694719
Location (UCSC)	Chr 5: 152.39 – 152.43 Mb	Chr 11: 56.02 – 56.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ligands

Agonists

• synephrine[8]

See also

• Neuromedin U receptor

References

1. GRCh38: Ensembl release 89: ENSG00000132911 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037393 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tate CG, Grisshammer R (Jan 1997). "Heterologous expression of G-protein-coupled receptors". Trends Biotechnol. 14 (11): 426–30. doi:10.1016/0167-7799(96)10059-7. PMID 8940772.
6. Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q (Jul 2000). "Identification of receptors for neuromedin U and its role in feeding". Nature. 406 (6791): 70–4. doi:10.1038/35017610. PMID 10894543.
7. "Entrez Gene: NMUR2 neuromedin U receptor 2".
8. Zheng X, Guo L, Wang D, Deng X (2014). "p-Synephrine: a novel agonist for neuromedin U2 receptor". Biol Pharm Bull. 37 (5): 764–70. doi:10.1248/bpb.b13-00788. PMID 24598981.

Further reading

• Hosoya M, Moriya T, Kawamata Y, et al. (2000). "Identification and functional characterization of a novel subtype of neuromedin U receptor". J. Biol. Chem. 275 (38): 29528–32. doi:10.1074/jbc.M004261200. PMID 10887190.
• Raddatz R, Wilson AE, Artymyshyn R, et al. (2000). "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system". J. Biol. Chem. 275 (42): 32452–9. doi:10.1074/jbc.M004613200. PMID 10899166.
• Shan L, Qiao X, Crona JH, et al. (2001). "Identification of a novel neuromedin U receptor subtype expressed in the central nervous system". J. Biol. Chem. 275 (50): 39482–6. doi:10.1074/jbc.C000522200. PMID 11010960.
• Fernández Alvarez C, Debeljuk L, Díaz Rodríguez E, Díaz López B (2003). "Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin". Peptides. 23 (9): 1617–23. doi:10.1016/S0196-9781(02)00099-2. PMID 12217422.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bhattacharyya S, Luan J, Farooqi IS, et al. (2004). "Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor". J. Endocrinol. 183 (1): 115–20. doi:10.1677/joe.1.05830. PMID 15525579.
• Mori K, Miyazato M, Ida T, et al. (2005). "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system". EMBO J. 24 (2): 325–35. doi:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449.
• Fang L, Zhang M, Li C, et al. (2006). "Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones". Neurosci. Lett. 404 (1–2): 148–53. doi:10.1016/j.neulet.2006.05.034. PMID 16781063.

External links

• "Neuromedin U Receptors: NMU2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.