Neuropeptide FF receptor 2

Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.[5]

NPFFR2
Identifiers
Aliases	NPFFR2, GPR74, HLWAR77, NPFF2, NPGPR, neuropeptide FF receptor 2
External IDs	OMIM: 607449 MGI: 1860130 HomoloGene: 56982 GeneCards: NPFFR2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 72,031,804 bp[1] End 72,148,067 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 89,527,429 bp[2] End 89,583,740 bp[2]
Gene ontology Molecular function • opioid receptor binding • peptide binding • G-protein coupled receptor activity • signal transducer activity • neuropeptide receptor activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane • actin cytoskeleton Biological process • G-protein coupled receptor signaling pathway • detection of abiotic stimulus • cellular response to hormone stimulus • regulation of MAPK cascade • regulation of adenylate cyclase activity • regulation of cAMP-dependent protein kinase activity • signal transduction • response to peptide • neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10886	104443
Ensembl	ENSG00000056291	ENSMUSG00000035528
UniProt	Q9Y5X5	Q924H0
RefSeq (mRNA)	NM_001144756 NM_004885 NM_053036	NM_133192
RefSeq (protein)	NP_001138228 NP_004876 NP_444264	NP_573455
Location (UCSC)	Chr 4: 72.03 – 72.15 Mb	Chr 5: 89.53 – 89.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Neuropeptide FF receptor

References

1. GRCh38: Ensembl release 89: ENSG00000056291 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035528 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NPFFR2 neuropeptide FF receptor 2".

Further reading

• Cikos S, Gregor P, Koppel J (1999). "Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta". Biochem. Biophys. Res. Commun. 256 (2): 352–6. doi:10.1006/bbrc.1999.0332. PMID 10079187.
• Parker RM, Copeland NG, Eyre HJ, et al. (2000). "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family". Brain Res. Mol. Brain Res. 77 (2): 199–208. doi:10.1016/S0169-328X(00)00052-8. PMID 10837915.
• Elshourbagy NA, Ames RS, Fitzgerald LR, et al. (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc.M004515200. PMID 10851242.
• Bonini JA, Jones KA, Adham N, et al. (2001). "Identification and characterization of two G protein-coupled receptors for neuropeptide FF". J. Biol. Chem. 275 (50): 39324–31. doi:10.1074/jbc.M004385200. PMID 11024015.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Laemmle B, Schindler M, Beilmann M, et al. (2003). "Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus". Regul. Pept. 111 (1–3): 21–9. doi:10.1016/S0167-0115(02)00220-3. PMID 12609745.
• Engström M, Wurster S, Savola JM, Panula P (2004). "Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors". Peptides. 24 (12): 1947–54. doi:10.1016/j.peptides.2003.10.009. PMID 15127947.
• Mollereau C, Mazarguil H, Zajac JM, Roumy M (2005). "Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells". Mol. Pharmacol. 67 (3): 965–75. doi:10.1124/mol.104.004614. PMID 15608144.
• Ankö ML, Panula P (2006). "Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line". J. Neurochem. 96 (2): 573–84. doi:10.1111/j.1471-4159.2005.03581.x. PMID 16336216.
• Ankö ML, Ostergård M, Lintunen M, Panula P (2007). "Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression". FEBS Lett. 580 (30): 6955–60. doi:10.1016/j.febslet.2006.11.063. PMID 17157836.
• Dahlman I, Dicker A, Jiao H, et al. (2007). "A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis". Am. J. Hum. Genet. 80 (6): 1115–24. doi:10.1086/518445. PMC 1867099. PMID 17503329.

External links

• "Neuropeptide FF Receptors: NPFF2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.