GPR177

G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene[5] that encodes a receptor for Wnt proteins in Wnt-secreting cells.[6]

WLS
Identifiers
Aliases	WLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator, Wnt ligand secretion mediator
External IDs	OMIM: 611514 MGI: 1915401 HomoloGene: 11779 GeneCards: WLS
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 68,098,473 bp[1] End 68,233,120 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H4 Start 159,839,672 bp[2] End 159,938,664 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • Wnt-protein binding • mu-type opioid receptor binding Cellular component • integral component of membrane • endocytic vesicle membrane • endosome • Golgi apparatus • early endosome membrane • membrane • cell membrane • dendrite membrane • trans-Golgi network • early endosome • dendrite cytoplasm • extracellular exosome • cytoplasmic vesicle membrane • endoplasmic reticulum membrane • cytoplasmic vesicle • Golgi membrane • endoplasmic reticulum Biological process • exocrine pancreas development • positive regulation of canonical Wnt signaling pathway • positive regulation of Wnt protein secretion • mesoderm formation • hindbrain development • multicellular organism development • positive regulation of Wnt signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • intracellular protein transport • anterior/posterior axis specification • midbrain development • Wnt signaling pathway • Wnt protein secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79971	68151
Ensembl	ENSG00000116729	ENSMUSG00000028173
UniProt	Q5T9L3	Q6DID7
RefSeq (mRNA)	NM_001002292 NM_001193334 NM_024911	NM_026582 NM_001356349 NM_001356350
RefSeq (protein)	NP_001002292 NP_001180263 NP_079187	NP_080858 NP_001343278 NP_001343279
Location (UCSC)	Chr 1: 68.1 – 68.23 Mb	Chr 3: 159.84 – 159.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Wntless was shown to be a cargo for the retromer complex.[6] It has been found essential for hair follicle induction.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116729 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028173 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR177 G protein-coupled receptor 177".
6. Eaton S (January 2008). "Retromer retrieves wntless". Developmental Cell. 14 (1): 4–6. doi:10.1016/j.devcel.2007.12.014. PMID 18194646.
7. Fu J, Hsu W (April 2013). "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis". The Journal of Investigative Dermatology. 133 (4): 890–8. doi:10.1038/jid.2012.407. PMC 3594635. PMID 23190887.

Further reading

• Bänziger C, Soldini D, Schütt C, Zipperlen P, Hausmann G, Basler K (May 2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells". Cell. 125 (3): 509–22. doi:10.1016/j.cell.2006.02.049. PMID 16678095.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.

See also

• GPR177+receptor,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.