FZD3

Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.[5][6][7]

FZD3
Identifiers
AliasesFZD3, Fz-3, frizzled class receptor 3
External IDsOMIM: 606143 MGI: 108476 HomoloGene: 23004 GeneCards: FZD3
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p21.1Start28,494,205 bp[1]
End28,574,267 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7976

14365

Ensembl

ENSG00000104290

ENSMUSG00000007989

UniProt

Q9NPG1

Q61086

RefSeq (mRNA)

NM_017412
NM_145866

NM_021458

RefSeq (protein)

NP_059108
NP_665873

NP_067433

Location (UCSC)Chr 8: 28.49 – 28.57 MbChr 14: 65.19 – 65.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[7]

The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[8][9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000104290 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000007989 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun. 271 (1): 8–14. doi:10.1006/bbrc.2000.2578. PMID 10777673.
  6. Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun. 273 (1): 27–34. doi:10.1006/bbrc.2000.2882. PMID 10873558.
  7. "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)".
  8. Hua ZL, Smallwood PM, Nathans J (Dec 2013). "Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons". eLife. 2: e01482. doi:10.7554/eLife.01482. PMC 3865743. PMID 24347548.
  9. Hua ZL, Jeon S, Caterina MJ, Nathans J (Jul 2014). "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system". Proc Natl Acad Sci U S A. 111 (29): E3005-14. doi:10.1073/pnas.1406399111. PMC 4115534. PMID 24799694.

Further reading

  • "Frizzled Receptors: FZD3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.