GPR183

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.[5]

GPR183
Identifiers
AliasesGPR183, EBI2, G protein-coupled receptor 183, hEBI2
External IDsOMIM: 605741 MGI: 2442034 HomoloGene: 28066 GeneCards: GPR183
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q32.3Start99,294,539 bp[1]
End99,307,399 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1880

321019

Ensembl

ENSG00000169508

ENSMUSG00000051212

UniProt

P32249

Q3U6B2

RefSeq (mRNA)

NM_004951

NM_183031

RefSeq (protein)

NP_004942

NP_898852

Location (UCSC)Chr 13: 99.29 – 99.31 MbChr 14: 121.95 – 121.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41.[6] This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes.[5]

EBI2 helps B cell homing within a lymph node. EBI2 expression increases during B cell activation, after B cell receptor and CD40 stimulation; its expression decreases during germinal cell development due to BCL6--a transcription factor required in germinal center development. EBI2 must turn off to move B cells to the germinal center from the periphery, and must turn on for B cells to exit the germinal center and re-enter the periphery.[7] EBI2 is a receptor for oxysterols, the most potent activator being 7α,25-dihydroxycholesterol.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000169508 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000051212 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: EBI2 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)".
  6. Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (Apr 1993). "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors". J Virol. 67 (4): 2209–20. PMC 240341. PMID 8383238.
  7. Pereira JP, Kelly LM, Xu Y, Cyster JG (Aug 2009). "EBI2 mediates B cell segregation between the outer and centre follicle". Nature. 460 (7259): 1122–6. doi:10.1038/nature08226. PMC 2809436. PMID 19597478.
  8. Liu C, Yang X, Wu J, Kuei C, Mani N, Zhang L, Yu J, Sutton S, Qin N, Banie H, Karlsson L, Sun S, Lovenberg T (Jul 2011). "Oxysterols direct immune cell migration via EBI2". Nature. 475 (7357): 524–7. doi:10.1038/nature10280. PMC 4297623. PMID 21796212.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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