Endothelin A receptor

Endothelin receptor type A, also known as ET_A, is a human G protein-coupled receptor.[5]

EDNRA
Identifiers
Aliases	EDNRA, ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR, MFDA, endothelin receptor type A
External IDs	OMIM: 131243 MGI: 105923 HomoloGene: 1478 GeneCards: EDNRA
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.22-q31.23 Start 147,480,917 bp[1] End 147,544,954 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C1 Start 77,663,031 bp[2] End 77,724,464 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • endothelin receptor activity • G-protein coupled receptor activity • signal transducer activity • GO:0001948 protein binding • phosphatidylinositol phospholipase C activity Cellular component • integral component of membrane • membrane • cell membrane • integral component of plasma membrane Biological process • smooth muscle contraction • response to hypoxia • neural crest cell development • vasoconstriction • head development • in utero embryonic development • activation of phospholipase C activity • respiratory gaseous exchange • activation of adenylate cyclase activity • regulation of blood pressure • endothelin receptor signaling pathway • enteric nervous system development • heart development • artery smooth muscle contraction • branching involved in blood vessel morphogenesis • cellular proliferation • signal transduction • positive regulation of cytosolic calcium ion concentration • G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • glucose transmembrane transport • regulation of glucose transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1909	13617
Ensembl	ENSG00000151617	ENSMUSG00000031616
UniProt	P25101	Q61614
RefSeq (mRNA)	NM_001166055 NM_001256283 NM_001957 NM_001354797	NM_010332
RefSeq (protein)	NP_001159527 NP_001948 NP_001341726	NP_034462
Location (UCSC)	Chr 4: 147.48 – 147.54 Mb	Chr 8: 77.66 – 77.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Endothelin receptor type A has been shown to interact with HDAC7A[6] and HTATIP.[6]

See also

• Endothelin receptor

References

1. GRCh38: Ensembl release 89: ENSG00000151617 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031616 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EDNRA endothelin receptor type A".
6. Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". The Journal of Biological Chemistry. 276 (20): 16597–600. doi:10.1074/jbc.C000909200. PMID 11262386.

External links

• "Endothelin Receptors: ET_A". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Arai H, Nakao K, Hosoda K, Ogawa Y, Nakagawa O, Komatsu Y, Imura H (1993). "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]". Japanese Circulation Journal. 56 Suppl 5: 1303–7. doi:10.1253/jcj.56.supplementv_1303. PMID 1291713.
• Hosoda K, Nakao K, Tamura N, Arai H, Ogawa Y, Suga S, Nakanishi S, Imura H (September 1992). "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor". The Journal of Biological Chemistry. 267 (26): 18797–804. PMID 1326535.
• Hayzer DJ, Rose PM, Lynch JS, Webb ML, Kienzle BK, Liu EC, Bogosian EA, Brinson E, Runge MS (October 1992). "Cloning and expression of a human endothelin receptor: subtype A". The American Journal of the Medical Sciences. 304 (4): 231–8. doi:10.1097/00000441-199210000-00002. PMID 1415318.
• Hosoda K, Nakao K, Suga S, Ogawa Y, Mukoyama M, Shirakami G, Saito Y, Nakanishi S, Imura H (August 1991). "Cloning and expression of human endothelin-1 receptor cDNA". FEBS Letters. 287 (1–2): 23–6. doi:10.1016/0014-5793(91)80007-P. PMID 1652463.
• Cyr C, Huebner K, Druck T, Kris R (November 1991). "Cloning and chromosomal localization of a human endothelin ETA receptor". Biochemical and Biophysical Research Communications. 181 (1): 184–90. doi:10.1016/S0006-291X(05)81399-3. PMID 1659806.
• Adachi M, Yang YY, Furuichi Y, Miyamoto C (November 1991). "Cloning and characterization of cDNA encoding human A-type endothelin receptor". Biochemical and Biophysical Research Communications. 180 (3): 1265–72. doi:10.1016/S0006-291X(05)81332-4. PMID 1719979.
• Lin HY, Kaji EH, Winkel GK, Ives HE, Lodish HF (April 1991). "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor". Proceedings of the National Academy of Sciences of the United States of America. 88 (8): 3185–9. doi:10.1073/pnas.88.8.3185. PMC 51410. PMID 1849646.
• Takigawa M, Sakurai T, Kasuya Y, Abe Y, Masaki T, Goto K (February 1995). "Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors". European Journal of Biochemistry / FEBS. 228 (1): 102–8. doi:10.1111/j.1432-1033.1995.tb20236.x. PMID 7882989.
• Kobayashi S, Tang R, Wang B, Opgenorth T, Langenstroer P, Shapiro E, Lepor H (February 1994). "Binding and functional properties of endothelin receptor subtypes in the human prostate". Molecular Pharmacology. 45 (2): 306–11. PMID 8114678.
• Yang H, Tabuchi H, Furuichi Y, Miyamoto C (January 1993). "Molecular characterization of the 5'-flanking region of human genomic ETA gene". Biochemical and Biophysical Research Communications. 190 (2): 332–9. doi:10.1006/bbrc.1993.1052. PMID 8427579.
• Elshourbagy NA, Korman DR, Wu HL, Sylvester DR, Lee JA, Nuthalaganti P, Bergsma DJ, Kumar CS, Nambi P (February 1993). "Molecular characterization and regulation of the human endothelin receptors". The Journal of Biological Chemistry. 268 (6): 3873–9. PMID 8440682.
• Miyamoto Y, Yoshimasa T, Arai H, Takaya K, Ogawa Y, Itoh H, Nakao K (February 1996). "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts". The Biochemical Journal. 313 (3): 795–801. doi:10.1042/bj3130795. PMC 1216980. PMID 8611157.
• Horstmeyer A, Cramer H, Sauer T, Müller-Esterl W, Schroeder C (August 1996). "Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification". The Journal of Biological Chemistry. 271 (34): 20811–9. doi:10.1074/jbc.271.34.20811. PMID 8702836.
• Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ (July 1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity". The Journal of Biological Chemistry. 272 (28): 17734–43. doi:10.1074/jbc.272.28.17734. PMID 9211925.
• Bourgeois C, Robert B, Rebourcet R, Mondon F, Mignot TM, Duc-Goiran P, Ferré F (September 1997). "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3". The Journal of Clinical Endocrinology and Metabolism. 82 (9): 3116–23. doi:10.1210/jc.82.9.3116. PMID 9284755.
• Mao XQ, Gao PS, Roberts MH, Enomoto T, Kawai M, Sasaki S, Shaldon SR, Coull P, Dake Y, Adra CN, Hagihara A, Shirakawa T, Hopkin JM (August 1999). "Variants of endothelin-1 and its receptors in atopic asthma". Biochemical and Biophysical Research Communications. 262 (1): 259–62. doi:10.1006/bbrc.1999.1158. PMID 10448102.
• Maggi M, Barni T, Fantoni G, Mancina R, Pupilli C, Luconi M, Crescioli C, Serio M, Vannelli GB (April 2000). "Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons". The Journal of Clinical Endocrinology and Metabolism. 85 (4): 1658–65. doi:10.1210/jc.85.4.1658. PMID 10770212.
• Shraga-Levine Z, Sokolovsky M (June 2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific". Cellular and Molecular Neurobiology. 20 (3): 305–17. doi:10.1023/A:1007010125316. PMID 10789830.
• Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". The Journal of Biological Chemistry. 276 (20): 16597–600. doi:10.1074/jbc.C000909200. PMID 11262386.
• Paasche JD, Attramadal T, Sandberg C, Johansen HK, Attramadal H (September 2001). "Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways". The Journal of Biological Chemistry. 276 (36): 34041–50. doi:10.1074/jbc.M103243200. PMID 11382773.
• Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ (April 2016). "Endothelin". Pharmacological Reviews. 68 (2): 357–418. doi:10.1124/pr.115.011833. PMC 4815360. PMID 26956245.
• Han SG, Ko S, Lee WK, Jung ST, Yu YG (August 2017). "Determination of the endothelin-1 recognition sites of endothelin receptor type A by the directed-degeneration method". Scientific Reports. 7 (1): 7577. doi:10.1038/s41598-017-08096-6. PMC 5548930.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.