FZD7

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.[5][6][7]

FZD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Z33
Identifiers
Aliases	FZD7, FzE3, frizzled class receptor 7
External IDs	OMIM: 603410 MGI: 108570 HomoloGene: 20751 GeneCards: FZD7
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 202,034,587 bp[1] End 202,038,445 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C2|1 30.08 cM Start 59,482,424 bp[2] End 59,486,955 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • PDZ domain binding • GO:0005110 frizzled binding • signal transducer activity • Wnt-protein binding • GO:0001948 protein binding • transmembrane signaling receptor activity • phosphatidylinositol-4,5-bisphosphate binding • G-protein coupled receptor activity • Wnt-activated receptor activity Cellular component • integral component of membrane • membrane • cell membrane • recycling endosome membrane • endosome • endosome membrane Biological process • negative regulation of cell-substrate adhesion • cellular response to retinoic acid • G-protein coupled receptor signaling pathway • non-canonical Wnt signaling pathway • regulation of transcription, DNA-templated • positive regulation of epithelial cell proliferation involved in wound healing • T cell differentiation in thymus • non-canonical Wnt signaling pathway via JNK cascade • negative regulation of ectodermal cell fate specification • somatic stem cell division • positive regulation of JNK cascade • Wnt signaling pathway • stem cell population maintenance • positive regulation of transcription, DNA-templated • multicellular organism development • cell surface receptor signaling pathway • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • neuron differentiation • canonical Wnt signaling pathway • substrate adhesion-dependent cell spreading • positive regulation of phosphorylation • signal transduction • mesenchymal to epithelial transition • Wnt signaling pathway, planar cell polarity pathway • negative regulation of cardiac muscle cell differentiation • regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8324	14369
Ensembl	ENSG00000155760	ENSMUSG00000041075
UniProt	O75084	Q61090
RefSeq (mRNA)	NM_003507	NM_008057
RefSeq (protein)	NP_003498	NP_032083
Location (UCSC)	Chr 2: 202.03 – 202.04 Mb	Chr 1: 59.48 – 59.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[7]

Interactions

FZD7 has been shown to interact with DLG4.[8]

See also

• Frizzled

References

1. GRCh38: Ensembl release 89: ENSG00000155760 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041075 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
6. Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
7. "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)".
8. Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. Netherlands. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714.

Further reading

• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene. 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vincan E, Darcy PK, Smyth MJ, et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation. 73 (4): 142–53. doi:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Vincan E, Darcy PK, Farrelly CA, et al. (2007). "Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids". Oncogene. 26 (16): 2340–52. doi:10.1038/sj.onc.1210026. PMID 17016432.
• Struewing IT, Barnett CD, Zhang W, et al. (2007). "Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1". Exp. Cell Res. 313 (16): 3526–41. doi:10.1016/j.yexcr.2007.07.012. PMID 17716656.

External links

• "Frizzled Receptors: FZD₇". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.