GPR45

Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.[5][6]

GPR45
Identifiers
Aliases	GPR45, PSP24, PSP24(ALPHA), PSP24A, G protein-coupled receptor 45
External IDs	OMIM: 604838 MGI: 2135882 HomoloGene: 5228 GeneCards: GPR45
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.1 Start 105,241,743 bp[1] End 105,243,467 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 42,952,872 bp[2] End 43,035,456 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • signal transduction • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11250	93690
Ensembl	ENSG00000135973	ENSMUSG00000041907
UniProt	Q9Y5Y3	Q9EQQ4
RefSeq (mRNA)	NM_007227	NM_053107
RefSeq (protein)	NP_009158	NP_444337
Location (UCSC)	Chr 2: 105.24 – 105.24 Mb	Chr 1: 42.95 – 43.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000135973 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041907 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.
6. "Entrez Gene: GPR45 G protein-coupled receptor 45".

Further reading

• Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.
• Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.