GPR124

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[5][6][7] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[8][9][10]

ADGRA2
Identifiers
Aliases	ADGRA2, G protein-coupled receptor 124, TEM5, GPR124, adhesion G protein-coupled receptor A2
External IDs	OMIM: 606823 MGI: 1925810 HomoloGene: 13112 GeneCards: ADGRA2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.23 Start 37,784,191 bp[1] End 37,844,896 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 27,085,583 bp[2] End 27,123,436 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • GO:0001948 protein binding • signal transducer activity • transmembrane signaling receptor activity Cellular component • integral component of membrane • cell surface • cell membrane • membrane • cell projection • filopodium Biological process • positive regulation of endothelial cell migration • G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • central nervous system development • negative regulation of vascular endothelial growth factor signaling pathway • sprouting angiogenesis • regulation of angiogenesis • endothelial cell migration • regulation of chemotaxis • angiogenesis • signal transduction • regulation of establishment of blood-brain barrier Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25960	78560
Ensembl	ENSG00000020181	ENSMUSG00000031486
UniProt	Q96PE1	Q91ZV8
RefSeq (mRNA)	NM_032777	NM_054044
RefSeq (protein)	NP_116166	NP_473385
Location (UCSC)	Chr 8: 37.78 – 37.84 Mb	Chr 8: 27.09 – 27.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GPR124 has been shown to interact with DLG1[11] and is involved in the Wnt/β-catenin signaling pathway along with RECK.[12]

Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.

References

1. GRCh38: Ensembl release 89: ENSG00000020181 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031486 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res. 61 (18): 6649–55. PMID 11559528.
6. Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (February 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
7. "Entrez Gene: GPR124 G protein-coupled receptor 124".
8. Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
9. Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
10. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
11. Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y (May 2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene. 23 (22): 3889–97. doi:10.1038/sj.onc.1207495. PMID 15021905.
12. Vanhollebeke B, Stone OA, Bostaille N, Cho C, Zhou Y, Maquet E, et al. (June 2015). Rossant J (ed.). "Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis". eLife. 4: e06489. doi:10.7554/eLife.06489. PMID 26051822.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yamamoto Y, Irie K, Asada M, et al. (2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene. 23 (22): 3889–97. doi:10.1038/sj.onc.1207495. PMID 15021905.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
• Vallon M, Essler M (2006). "Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans". J. Biol. Chem. 281 (45): 34179–88. doi:10.1074/jbc.M605291200. PMID 16982628.