Diacylglycerol lipase
Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.[1] It catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol.
| diacylglycerol lipase, alpha | |
|---|---|
| Identifiers | |
| Symbol | DAGLA |
| Alt. symbols | C11orf11 |
| NCBI gene | 747 |
| HGNC | 1165 |
| RefSeq | NM_006133 |
| UniProt | Q9Y4D2 |
| Other data | |
| EC number | 3.1.1.- |
| Locus | Chr. 11 q12.3 |
| diacylglycerol lipase, beta | |
|---|---|
| Identifiers | |
| Symbol | DAGLB |
| NCBI gene | 221955 |
| HGNC | 28923 |
| RefSeq | NM_139179 |
| UniProt | Q8NCG7 |
| Other data | |
| EC number | 3.1.1.- |
| Locus | Chr. 7 p22.1 |
Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.
Inhibitors
The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.
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References
- Bisogno T, Howell F, Williams G, et al. (November 2003). "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain". J. Cell Biol. 163 (3): 463–8. doi:10.1083/jcb.200305129. PMC 2173631. PMID 14610053.
External links
- Diacylglycerol+Lipase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.1.1.34
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