Proquazone

Proquazone
Clinical data
ATC code	M01AX13 (WHO) ;
Identifiers
	IUPAC name 1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one;
CAS Number	22760-18-5 ;
PubChem CID	31508;
ChemSpider	29222 ;
UNII	42VPJ2980S;
ChEMBL	ChEMBL268501 ;
CompTox Dashboard (EPA)	DTXSID4021210 ;
ECHA InfoCard	100.041.079
Chemical and physical data
Formula	C18H18N2O
Molar mass	278.355 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3;
	InChI InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3 ; Key:JTIGKVIOEQASGT-UHFFFAOYSA-N ;
	(what is this?) (verify)

Proquazone is a nonsteroidal anti-inflammatory drug, known as a NSAID.[1]

Synthesis

[2] [3]

gollark: Oh, sure, fights with people who actually want to participate in them would be okay.

gollark: You still run into externalities like, er, carbon dioxide.

gollark: Ideally we'd be able to partition Earth into... lots of... different areas, set up different governments in each with people who like each one in them, magically fix externalities between them and stop them going to war or something, somehow deal with the issue of ensuring children in each society have a reasonable choice of where to go, and allowing people to be exiled to some other society in lieu of punishment there - assuming other ones will take them, obviously. But that is impractical.

gollark: The reason I support *some* land-value-taxish thing is that nobody creates land, so reward from it should probably go to everyone.

gollark: The only big problem I can see with that is that you can't really have the property/developed stuff on that land separate from the land itself, at least with current technology and use of nonmovable stuff.

References

Clissold SP, Beresford R (May 1987). "Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states". Drugs. 33 (5): 478–502. doi:10.2165/00003495-198733050-00004. PMID 3297621.
Coombs RV, Danna RP, Denzer M, Hardtmann GE, Huegi B, Koletar G, et al. (November 1973). "Synthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolinones and quinazolinethiones". Journal of Medicinal Chemistry. 16 (11): 1237–45. doi:10.1021/jm00269a006. PMID 4747965.
GB 1592687, Gamboni G, Schmid W, Sutter A, "Process for Production of 4-Phenyl-2-(1H)-quinazolinones", issued 1981, assigned to Sandoz

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Clissold SP, Beresford R (May 1987). "Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states". Drugs. 33 (5): 478–502. doi:10.2165/00003495-198733050-00004. PMID 3297621.

[CoombsDanna1973-2] Coombs RV, Danna RP, Denzer M, Hardtmann GE, Huegi B, Koletar G, et al. (November 1973). "Synthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolinones and quinazolinethiones". Journal of Medicinal Chemistry. 16 (11): 1237–45. doi:10.1021/jm00269a006. PMID 4747965.

[3] GB 1592687, Gamboni G, Schmid W, Sutter A, "Process for Production of 4-Phenyl-2-(1H)-quinazolinones", issued 1981, assigned to Sandoz

Nonsteroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
Oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam
Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
N-Arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin
Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap
Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.