Cimicoxib
Cimicoxib (UR-8880 trade name Cimalgex) is a nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine to treat dogs for pain and inflammation associated with osteoarthritis and for the management of pain and inflammation associated with surgery.[1] It acts as a COX-2 inhibitor.
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| Names | |
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| IUPAC name
4-[4-Chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]benzenesulfonamide | |
| Identifiers | |
3D model (JSmol) |
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.170.774 |
PubChem CID |
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CompTox Dashboard (EPA) |
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| Properties | |
| C16H13ClFN3O3S | |
| Molar mass | 381.81 g·mol−1 |
| Pharmacology | |
| QM01AH93 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Synthesis
Cimicoxib synthesis:[2]
Reaction of the imine with TosMIC in the presence of potassium carbonate leads to what may be viewed as 2+3 cycloaddition of the nitrogen analogue of a ketene to form the imidazole ring.
gollark: That's how you would do it in my thing, using a somewhat insane S-expression assembly-ish language.
gollark: Using hypothetical assembly syntax I haven't actually implemented:```# start of memory to add kittens to(add r1 r0 0x1000) # maybe there would be nice dedicated syntax for "set register" actually# end of kittenized region(add r2 r0 0x1600)(label loop (add r3 r0 40) (poke r3 r1 0) (add r3 r0 94) (poke r3 r1 1) # and so on (add r1 r1 8) (jlt r1 r2 loop))```
gollark: To create RAM kittens, all you need to do is `ADD` the ASCII value of each character into a temporary register, `POKE` them into the right memory location (using the per-instruction `POKE` offset, probably), and then do that in a loop.
gollark: I should probably implement arithmetic instructions then a basic assembler, I guess, because hand-writing machine code is unpleasant.
gollark: What? No. This doesn't really need jumps, except possibly to run it repeatedly.
References
- "European Public Assessment Report: Cimalgex (cimicoxib)". European Medicines Agency.
- Almansa, Carmen; Alfón, José; de Arriba, Alberto F.; Cavalcanti, Fernando L.; Escamilla, Ignasi; Gómez, Luis A.; Miralles, Agustí; Soliva, Robert; Bartrolí, Javier; Carceller, Elena; Merlos, Manuel; García-Rafanell, Julián (2003). "Synthesis and Structure−Activity Relationship of a New Series of COX-2 Selective Inhibitors: 1,5-Diarylimidazoles". Journal of Medicinal Chemistry. 46 (16): 3463–3475. doi:10.1021/jm030765s. ISSN 0022-2623. PMID 12877584.
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