ALPI

Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.[5][6]

ALPI
Identifiers
Aliases	ALPI, IAP, alkaline phosphatase, intestinal
External IDs	OMIM: 171740 MGI: 87984 HomoloGene: 134333 GeneCards: ALPI
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 232,456,125 bp[1] End 232,460,753 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C5|1 44.06 cM Start 87,124,973 bp[2] End 87,127,912 bp[2]
Gene ontology Molecular function • protease binding • phosphatase activity • zinc ion binding • GO:0001948 protein binding • catalytic activity • hydrolase activity • magnesium ion binding • metal ion binding • alkaline phosphatase activity Cellular component • integral component of membrane • anchored component of membrane • membrane • extracellular region • cell membrane Biological process • metabolism • dephosphorylation • phosphatidic acid biosynthetic process • digestion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	248	11648
Ensembl	ENSG00000163295	ENSMUSG00000036500
UniProt	P09923	P24822
RefSeq (mRNA)	NM_001631	NM_007432
RefSeq (protein)	NP_001622	n/a
Location (UCSC)	Chr 2: 232.46 – 232.46 Mb	Chr 1: 87.12 – 87.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000163295 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036500 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Berger J, Garattini E, Hua JC, Udenfriend S (February 1987). "Cloning and sequencing of human intestinal alkaline phosphatase cDNA". Proc. Natl. Acad. Sci. U.S.A. 84 (3): 695–8. doi:10.1073/pnas.84.3.695. PMC 304282. PMID 3468508.
6. Henthorn PS, Raducha M, Edwards YH, Weiss MJ, Slaughter C, Lafferty MA, Harris H (March 1987). "Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase". Proc. Natl. Acad. Sci. U.S.A. 84 (5): 1234–8. doi:10.1073/pnas.84.5.1234. PMC 304401. PMID 3469665.

External links

• Human ALPI genome location and ALPI gene details page in the UCSC Genome Browser.

Further reading

• Hirasaka K, Tokuoka K, Nakao R, et al. (2008). "Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells". J Physiol Sci. 58 (2): 105–11. doi:10.2170/physiolsci.RP013007. PMID 18307834.
• Mahmood A, Shao JS, Alpers DH (2003). "Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2): G433–41. doi:10.1152/ajpgi.00466.2002. PMID 12660142.
• Wada A, Wang AP, Isomoto H, et al. (2005). "Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin". Int. J. Med. Microbiol. 294 (7): 427–35. doi:10.1016/j.ijmm.2004.09.012. PMID 15715171.
• Nakano T, Inoue I, Alpers DH, et al. (2009). "Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration". Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1): G207–14. doi:10.1152/ajpgi.90590.2008. PMC 3817256. PMID 19407215.
• Malo MS, Zhang W, Alkhoury F, et al. (2004). "Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element". Mol. Endocrinol. 18 (8): 1941–62. doi:10.1210/me.2003-0351. PMID 15143152.
• Rump A, Kasper G, Hayes C, et al. (2001). "Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1". Genomics. 73 (1): 50–5. doi:10.1006/geno.2000.6504. PMID 11352565.
• Nauli AM, Zheng S, Yang Q, et al. (2003). "Intestinal alkaline phosphatase release is not associated with chylomicron formation". Am. J. Physiol. Gastrointest. Liver Physiol. 284 (4): G583–7. doi:10.1152/ajpgi.00482.2002. PMID 12466148.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Alkhoury F, Malo MS, Mozumder M, et al. (2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G285–90. doi:10.1152/ajpgi.00037.2005. PMID 15774940.
• Giatromanolaki A, Sivridis E, Maltezos E, Koukourakis MI (2002). "Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity". Semin. Oncol. 29 (6 Suppl 19): 14–21. doi:10.1053/sonc.2002.37356. PMID 12577238.
• Torres MI, Lorite P, López-Casado MA, Ríos A (2007). "A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease". Pathol. Res. Pract. 203 (6): 485–7. doi:10.1016/j.prp.2007.02.003. PMID 17498884.
• Hinnebusch BF, Siddique A, Henderson JW, et al. (2004). "Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor". Am. J. Physiol. Gastrointest. Liver Physiol. 286 (1): G23–30. doi:10.1152/ajpgi.00203.2003. PMID 12919939.
• Le Du MH, Millan JL (2002). "Structural evidence of functional divergence in human alkaline phosphatases". J. Biol. Chem. 277 (51): 49808–14. doi:10.1074/jbc.M207394200. PMID 12372831.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Goldberg RF, Austen WG, Zhang X, et al. (2008). "Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3551–6. doi:10.1073/pnas.0712140105. PMC 2265168. PMID 18292227.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Olsen L, Bressendorff S, Troelsen JT, Olsen J (2005). "Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G220–6. doi:10.1152/ajpgi.00449.2004. PMID 15831710.
• Fumoto K, Hoogenraad CC, Kikuchi A (2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome". EMBO J. 25 (24): 5670–82. doi:10.1038/sj.emboj.7601459. PMC 1698904. PMID 17139249.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.