Azapropazone

Azapropazone is a nonsteroidal anti-inflammatory drug (NSAID). It is manufactured by Goldshield under the tradename Rheumox.[1]

Azapropazone

Clinical data
Trade names	Rheumox
AHFS/Drugs.com	International Drug Names
ATC code	M01AX04 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Elimination half-life	20 hours
Identifiers
IUPAC name (RS)-5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione
CAS Number	13539-59-8^N
PubChem CID	26098
ChemSpider	24310^Y
UNII	K2VOT966ZI
KEGG	D02966^Y
ChEBI	CHEBI:38010^Y
ChEMBL	ChEMBL1231131^N
CompTox Dashboard (EPA)	DTXSID6045408
ECHA InfoCard	100.033.543
Chemical and physical data
Formula	C16H20N4O2
Molar mass	300.362 g·mol^−1
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES O=C3N/1N(c2c(\N=C\1N(C)C)ccc(c2)C)C(=O)C3CCC
InChI InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3^Y Key:MPHPHYZQRGLTBO-UHFFFAOYSA-N^Y
^NY (what is this?)  (verify)

It was available in the UK as a prescription-only drug, with restrictions due to certain contra-indications and side-effects.[2] Azopropazone has now been discontinued in the British National Formulary.

Azapropazone has a half-life of approximately 20 hours in humans and is not extensively metabolized.[3]

References

1. "Rheumox Capsules". South Africa Electronic Package Inserts.
2. "Azapropazone". Patient UK. Archived from the original on 12 April 2009.
3. Jones CJ (1976). "The pharmacology and pharmacokinetics of azapropazone - a review". Current Medical Research and Opinion. 4 (1): 3–16. doi:10.1185/03007997609109361. PMID 770078.