60S ribosomal protein L35a

60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35A gene.[5][6][7]

RPL35A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J92, 4UJC, 3J7P, 4UJE, 3J7Q, 3J7R, 4D67, 4UJD, 4D5Y, 3J7O
Identifiers
Aliases	RPL35A, DBA5, L35A, ribosomal protein L35a, eL33
External IDs	OMIM: 180468 MGI: 1928894 HomoloGene: 129020 GeneCards: RPL35A
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q29 Start 197,950,190 bp[1] End 197,956,610 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 33,056,453 bp[2] End 33,060,189 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • tRNA binding • RNA binding • structural constituent of ribosome Cellular component • cytosol • ribosome • membrane • intracellular • cytosolic large ribosomal subunit • extracellular exosome • extracellular matrix Biological process • viral transcription • SRP-dependent cotranslational protein targeting to membrane • ribosomal large subunit biogenesis • translational initiation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • protein biosynthesis • rRNA processing • cytoplasmic translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6165	57808
Ensembl	ENSG00000182899	ENSMUSG00000060636
UniProt	P18077	O55142
RefSeq (mRNA)	NM_000996 NM_001316311	NM_001130484 NM_001130485 NM_021338
RefSeq (protein)	NP_000987 NP_001303240	NP_001123956 NP_001123957 NP_067313
Location (UCSC)	Chr 3: 197.95 – 197.96 Mb	Chr 16: 33.06 – 33.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000182899 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060636 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Feo S, Davies B, Fried M (Jun 1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome". Genomics. 13 (1): 201–7. doi:10.1016/0888-7543(92)90221-D. PMID 1577483.
6. Colombo P, Read M, Fried M (Sep 1996). "The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter". Genomics. 32 (1): 148–50. doi:10.1006/geno.1996.0093. PMID 8786106.
7. "Entrez Gene: RPL35A ribosomal protein L35a".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Herzog H, Höfferer L, Schneider R, Schweiger M (1990). "cDNA encoding the human homologue of rat ribosomal protein L35a". Nucleic Acids Res. 18 (15): 4600. doi:10.1093/nar/18.15.4600. PMC 331293. PMID 2388839.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Kroes RA, Jastrow A, McLone MG, et al. (2000). "The identification of novel therapeutic targets for the treatment of malignant brain tumors". Cancer Lett. 156 (2): 191–8. doi:10.1016/S0304-3835(00)00462-6. PMID 10880769.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
• Lopez CD, Martinovsky G, Naumovski L (2002). "Inhibition of cell death by ribosomal protein L35a". Cancer Lett. 180 (2): 195–202. doi:10.1016/S0304-3835(02)00024-1. PMID 12175552.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kasai H, Nadano D, Hidaka E, et al. (2003). "Differential expression of ribosomal proteins in human normal and neoplastic colorectum". J. Histochem. Cytochem. 51 (5): 567–74. doi:10.1177/002215540305100502. PMID 12704204.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia