EIF3K

Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene.[5][6][7]

EIF3K
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RZ4, 3J8B, 3J8C
Identifiers
Aliases	EIF3K, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001, ARG134, eukaryotic translation initiation factor 3 subunit K
External IDs	OMIM: 609596 MGI: 1921080 HomoloGene: 8292 GeneCards: EIF3K
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 38,619,082 bp[1] End 38,636,955 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 28,971,372 bp[2] End 28,981,864 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ribosome binding • GO:0001948 protein binding • translation initiation factor activity • RNA binding Cellular component • eukaryotic translation initiation factor 3 • extracellular exosome • membrane • cell nucleus • cytoplasm • cytosol • eukaryotic 43S preinitiation complex • eukaryotic 48S preinitiation complex Biological process • translational initiation • regulation of translational initiation • protein biosynthesis • formation of cytoplasmic translation initiation complex • cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27335	73830
Ensembl	ENSG00000178982 ENSG00000282986	ENSMUSG00000053565
UniProt	Q9UBQ5	Q9DBZ5
RefSeq (mRNA)	NM_001300992 NM_001308393 NM_013234	NM_001285942 NM_001285943 NM_028659
RefSeq (protein)	NP_001287921 NP_001295322 NP_037366	NP_001272871 NP_001272872 NP_082935
Location (UCSC)	Chr 19: 38.62 – 38.64 Mb	Chr 7: 28.97 – 28.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The ~800 kDa eukaryotic initiation factor 3 (eIF3) is the largest eIF and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 43S preinitiation complex.[8][7]

Interactions

eIF3k has been shown to interact with Cyclin D3[9] and eIF3a.[6][10]

See also

• Eukaryotic initiation factor 3 (eIF3)

References

1. ENSG00000282986 GRCh38: Ensembl release 89: ENSG00000178982, ENSG00000282986 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053565 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
6. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". European Journal of Biochemistry. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
7. "Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12".
8. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". European Journal of Biochemistry. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
9. Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J (August 2004). "Identification of the p28 subunit of eukaryotic initiation factor 3 (eIF3k) as a new interaction partner of cyclin D3". FEBS Letters. 573 (1–3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.
10. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

• Karki S, Ligon LA, DeSantis J, Tokito M, Holzbaur EL (May 2002). "PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact". Molecular Biology of the Cell. 13 (5): 1722–34. doi:10.1091/mbc.02-02-0011. PMC 111139. PMID 12006665.
• Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W (August 2004). "Crystal structure of human eIF3k, the first structure of eIF3 subunits". The Journal of Biological Chemistry. 279 (33): 34983–90. doi:10.1074/jbc.M405158200. PMID 15180986.
• Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J (August 2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Letters. 573 (1–3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9UBQ5 (Human Eukaryotic translation initiation factor 3 subunit K (EIF3K)) at the PDBe-KB.