MRPL39

39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene.[5][6]

MRPL39
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL39, C21orf92, L39mt, MRP-L5, MRPL5, PRED22, PRED66, RPML5, MSTP003, mitochondrial ribosomal protein L39, L5mt
External IDs	OMIM: 611845 MGI: 1351620 HomoloGene: 9679 GeneCards: MRPL39
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 25,585,656 bp[1] End 25,607,517 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 84,717,576 bp[2] End 84,735,742 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • RNA binding Cellular component • mitochondrial inner membrane • ribosome • mitochondrial ribosome • mitochondrial large ribosomal subunit • mitochondrion Biological process • mitochondrial translational elongation • mitochondrial translational termination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54148	27393
Ensembl	ENSG00000154719	ENSMUSG00000022889
UniProt	Q9NYK5	Q9JKF7
RefSeq (mRNA)	NM_017446 NM_080794	NM_017404 NM_001384093 NM_001384095 NM_001384096
RefSeq (protein)	NP_059142 NP_542984	NP_059100 NP_001371022 NP_001371024 NP_001371025
Location (UCSC)	Chr 21: 25.59 – 25.61 Mb	Chr 16: 84.72 – 84.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000154719 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022889 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
6. "Entrez Gene: MRPL39 mitochondrial ribosomal protein L39".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• O'Brien TW, Fiesler SE, Denslow ND, et al. (2000). "Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 274 (51): 36043–51. doi:10.1074/jbc.274.51.36043. PMID 10593885.
• Spirina O, Bykhovskaya Y, Kajava AV, et al. (2001). "Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing)". Gene. 261 (2): 229–34. doi:10.1016/S0378-1119(00)00504-7. PMID 11167009.
• O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease". Gene. 286 (1): 73–9. doi:10.1016/S0378-1119(01)00808-3. PMID 11943462.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.