EIF3J

Eukaryotic translation initiation factor 3 subunit J (eIF3j) is a protein that in humans is encoded by the EIF3J gene.[4][5]

EIF3J
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KRB, 3BPJ
Identifiers
Aliases	EIF3J, EIF3S1, eIF3-alpha, eIF3-p35, eukaryotic translation initiation factor 3 subunit J
External IDs	OMIM: 603910 MGI: 3704486 HomoloGene: 37845 GeneCards: EIF3J
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.1 Start 44,537,125 bp[1] End 44,563,029 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • translation initiation factor activity Cellular component • cytoplasm • eukaryotic translation initiation factor 3 • cytosol • eukaryotic 43S preinitiation complex • eukaryotic 48S preinitiation complex Biological process • translational initiation • protein biosynthesis • formation of cytoplasmic translation initiation complex • cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8669	100042807
Ensembl	ENSG00000104131	n/a
UniProt	O75822	Q66JS6
RefSeq (mRNA)	NM_003758 NM_001284335 NM_001284336	NM_001256055
RefSeq (protein)	NP_001271264 NP_001271265 NP_003749	NP_001242984
Location (UCSC)	Chr 15: 44.54 – 44.56 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

eIF3j has been shown to interact with eIF3a.[4][6]

See also

• Eukaryotic initiation factor 3 (eIF3)

References

1. GRCh38: Ensembl release 89: ENSG00000104131 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Block KL, Vornlocher HP, Hershey JW (Dec 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. PMID 9822659.
5. "Entrez Gene: EIF3S1 eukaryotic translation initiation factor 3, subunit 1 alpha, 35kDa".
6. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.

Further reading

• Asano K, Kinzy TG, Merrick WC, Hershey JW (1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3". J. Biol. Chem. 272 (2): 1101–9. doi:10.1074/jbc.272.2.1101. PMID 8995409.
• Méthot N, Rom E, Olsen H, Sonenberg N (1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc.272.2.1110. PMID 8995410.
• Bushell M, Wood W, Clemens MJ, Morley SJ (2000). "Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis". Eur. J. Biochem. 267 (4): 1083–91. doi:10.1046/j.1432-1327.2000.01101.x. PMID 10672017.
• Valásek L, Hasek J, Nielsen KH, Hinnebusch AG (2001). "Dual function of eIF3j/Hcr1p in processing 20 S pre-rRNA and translation initiation". J. Biol. Chem. 276 (46): 43351–60. doi:10.1074/jbc.M106887200. PMID 11560931.
• Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
• Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW (2004). "The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro". J. Biol. Chem. 279 (10): 8946–56. doi:10.1074/jbc.M312745200. PMID 14688252.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• ElAntak L, Tzakos AG, Locker N, Lukavsky PJ (2007). "Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit" (PDF). J. Biol. Chem. 282 (11): 8165–74. doi:10.1074/jbc.M610860200. PMID 17190833.

External links

• Overview of all the structural information available in the PDB for UniProt: O75822 (Human Eukaryotic translation initiation factor 3 subunit J (EIF3J)) at the PDBe-KB.