EEF1E1

Eukaryotic translation elongation factor 1 epsilon-1 is a protein that in humans is encoded by the EEF1E1 gene.[4][5]

EEF1E1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2UZ8, 4BL7, 4BVX, 4BVY, 5BMU
Identifiers
Aliases	EEF1E1, AIMP3, P18, eukaryotic translation elongation factor 1 epsilon 1
External IDs	OMIM: 609206 MGI: 1913393 HomoloGene: 3161 GeneCards: EEF1E1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p24.3 Start 8,073,360 bp[1] End 8,102,559 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • glutathione transferase activity Cellular component • nucleoplasm • nucleolus • cell nucleus • cytoplasm • aminoacyl-tRNA synthetase multienzyme complex • cytosol Biological process • positive regulation of apoptotic process • positive regulation of DNA damage response, signal transduction by p53 class mediator • tRNA aminoacylation for protein translation • protein biosynthesis • positive regulation of cellular senescence • negative regulation of cell proliferation • glutathione metabolic process • cellular response to leukemia inhibitory factor • positive regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9521	66143
Ensembl	ENSG00000124802	n/a
UniProt	O43324	Q9D1M4
RefSeq (mRNA)	NM_004280 NM_001135650	NM_025380
RefSeq (protein)	NP_001129122 NP_004271	NP_079656
Location (UCSC)	Chr 6: 8.07 – 8.1 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000124802 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
5. "Entrez Gene: EEF1E1 eukaryotic translation elongation factor 1 epsilon 1".

Further reading

• Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents". J. Biol. Chem. 266 (23): 15398–405. PMID 1651330.
• Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". J. Mol. Biol. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID 9878398.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ahn HC, Kim S, Lee BJ (2003). "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43". FEBS Lett. 542 (1–3): 119–24. doi:10.1016/S0014-5793(03)00362-4. PMID 12729910.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Park BJ, Kang JW, Lee SW, et al. (2005). "The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR". Cell. 120 (2): 209–21. doi:10.1016/j.cell.2004.11.054. PMID 15680327.

External links

• Overview of all the structural information available in the PDB for UniProt: O43324 (Human Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1)) at the PDBe-KB.