MRPL37

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.[5][6]

MRPL37
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL37, L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mitochondrial ribosomal protein L37, L2mt
External IDs	OMIM: 611843 MGI: 1926268 HomoloGene: 9536 GeneCards: MRPL37
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 54,184,041 bp[1] End 54,225,464 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C7 Start 107,055,874 bp[2] End 107,066,868 bp[2]
Gene ontology Molecular function • structural constituent of ribosome • RNA binding Cellular component • mitochondrial inner membrane • ribosome • mitochondrial ribosome • mitochondrial large ribosomal subunit • mitochondrion Biological process • mitochondrial translational elongation • mitochondrial translational termination • protein biosynthesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51253	56280
Ensembl	ENSG00000116221	ENSMUSG00000028622
UniProt	Q9BZE1	Q921S7
RefSeq (mRNA)	NM_016491 NM_001330602	NM_025500
RefSeq (protein)	NP_001317531 NP_057575	NP_079776
Location (UCSC)	Chr 1: 54.18 – 54.23 Mb	Chr 4: 107.06 – 107.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000116221 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028622 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Graack HR, Bryant ML, O'Brien TW (Jan 2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–77. doi:10.1021/bi991543s. PMID 10600119.
6. "Entrez Gene: MRPL37 mitochondrial ribosomal protein L37".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Levshenkova EV, Ukraintsev KE, Orlova VV, et al. (2005). "[The structure and specific features of the cDNA expression of the human gene MRPL37]". Bioorg. Khim. 30 (5): 499–506. PMID 15562971.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9BZE1 (39S ribosomal protein L37, mitochondrial) at the PDBe-KB.