EEF1D

Elongation factor 1-delta is a protein that in humans is encoded by the EEF1D gene.[5]

EEF1D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MVM, 2MVN, 2N51
Identifiers
Aliases	EEF1D, EF-1D, EF1D, FP1047, eukaryotic translation elongation factor 1 delta
External IDs	OMIM: 130592 MGI: 1913906 HomoloGene: 23404 GeneCards: EEF1D
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 143,579,697 bp[1] End 143,599,541 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 75,894,205 bp[2] End 75,909,556 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • heat shock protein binding • translation factor activity, RNA binding • activating transcription factor binding • signal transducer activity • translation elongation factor activity • GO:0001948 protein binding • cadherin binding Cellular component • cytoplasm • endoplasmic reticulum • cell nucleus • eukaryotic translation elongation factor 1 complex • fibrillar center • cytosol Biological process • regulation of transcription, DNA-templated • regulation of cell death • translational elongation • mRNA transcription • transcription, DNA-templated • cellular response to ionizing radiation • positive regulation of I-kappaB kinase/NF-kappaB signaling • signal transduction • protein biosynthesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1936	66656
Ensembl	ENSG00000104529 ENSG00000273594	ENSMUSG00000055762
UniProt	P29692	P57776
RefSeq (mRNA)	NM_001130053 NM_001130054 NM_001130055 NM_001130056 NM_001130057 NM_001195203 NM_001289950 NM_001960 NM_032378 NM_001317743 NM_001330646	NM_001285429 NM_001285430 NM_001285431 NM_001285432 NM_001285433 NM_001285434 NM_023240 NM_029663
RefSeq (protein)	NP_001123525 NP_001123527 NP_001123528 NP_001123529 NP_001182132 NP_001276879 NP_001304672 NP_001317575 NP_001951 NP_115754	NP_001272358 NP_001272359 NP_001272360 NP_001272361 NP_001272362 NP_001272363 NP_075729 NP_083939
Location (UCSC)	Chr 8: 143.58 – 143.6 Mb	Chr 15: 75.89 – 75.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants have been found for this gene, however, the full length nature of only two variants has been determined.[6]

Interactions

EEF1D has been shown to interact with Glycyl-tRNA synthetase,[7] EEF1G[8][9] and KTN1,[10] and is predicted to interact with TMEM63A.[11]

References

1. ENSG00000273594 GRCh38: Ensembl release 89: ENSG00000104529, ENSG00000273594 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055762 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sanders J, Raggiaschi R, Morales J, Möller W (Jul 1993). "The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1174 (1): 87–90. doi:10.1016/0167-4781(93)90097-W. PMID 8334168.
6. "Entrez Gene: EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)".
7. Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
9. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
10. Ong LL, Er CP, Ho A, Aung MT, Yu H (Aug 2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". The Journal of Biological Chemistry. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547.
11. "String Database". Retrieved 16 May 2014.

Further reading

• Venema RC, Peters HI, Traugh JA (Jul 1991). "Phosphorylation of elongation factor 1 (EF-1) and valyl-tRNA synthetase by protein kinase C and stimulation of EF-1 activity". The Journal of Biological Chemistry. 266 (19): 12574–80. PMID 2061327.
• van Damme HT, Amons R, Karssies R, Timmers CJ, Janssen GM, Möller W (Aug 1990). "Elongation factor 1 beta of artemia: localization of functional sites and homology to elongation factor 1 delta". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1050 (1–3): 241–7. doi:10.1016/0167-4781(90)90174-z. PMID 2207149.
• Bec G, Kerjan P, Zha XD, Waller JP (Dec 1989). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry. 264 (35): 21131–7. PMID 2556394.
• Wolfson AD, Orlovsky AF, Gladilin KL (Oct 1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters. 238 (2): 262–4. doi:10.1016/0014-5793(88)80492-7. PMID 3169261.
• Mulner-Lorillon O, Minella O, Cormier P, Capony JP, Cavadore JC, Morales J, Poulhe R, Bellé R (Aug 1994). "Elongation factor EF-1 delta, a new target for maturation-promoting factor in Xenopus oocytes". The Journal of Biological Chemistry. 269 (31): 20201–7. PMID 8051108.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bec G, Kerjan P, Waller JP (Jan 1994). "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation". The Journal of Biological Chemistry. 269 (3): 2086–92. PMID 8294461.
• Sanders J, Brandsma M, Janssen GM, Dijk J, Möller W (May 1996). "Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum". Journal of Cell Science. 109 (5): 1113–7. PMID 8743958.
• Chang YW, Traugh JA (Nov 1997). "Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation". The Journal of Biological Chemistry. 272 (45): 28252–7. doi:10.1074/jbc.272.45.28252. PMID 9353277.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Sheu GT, Traugh JA (Dec 1997). "Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII". The Journal of Biological Chemistry. 272 (52): 33290–7. doi:10.1074/jbc.272.52.33290. PMID 9407120.
• Xiao H, Neuveut C, Benkirane M, Jeang KT (Mar 1998). "Interaction of the second coding exon of Tat with human EF-1 delta delineates a mechanism for HIV-1-mediated shut-off of host mRNA translation". Biochemical and Biophysical Research Communications. 244 (2): 384–9. doi:10.1006/bbrc.1998.8274. PMID 9514931.
• Kolettas E, Lymboura M, Khazaie K, Luqmani Y (1998). "Modulation of elongation factor-1 delta (EF-1 delta) expression by oncogenes in human epithelial cells". Anticancer Research. 18 (1A): 385–92. PMID 9568107.
• Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
• Chacko G, Ling Q, Hajjar KA (Jul 1998). "Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta". The Journal of Biological Chemistry. 273 (31): 19840–6. doi:10.1074/jbc.273.31.19840. PMID 9677419.
• Sheu GT, Traugh JA (Jan 1999). "A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII". Molecular and Cellular Biochemistry. 191 (1–2): 181–6. doi:10.1023/A:1006802125856. PMID 10094407.
• Furusawa T, Moribe H, Kondoh H, Higashi Y (Dec 1999). "Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1". Molecular and Cellular Biology. 19 (12): 8581–90. doi:10.1128/mcb.19.12.8581. PMC 84984. PMID 10567582.
• Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
• Lei YX, Chen JK, Wu ZL (2002). "Blocking the translation elongation factor-1 delta with its antisense mRNA results in a significant reversal of its oncogenic potential". Teratogenesis, Carcinogenesis, and Mutagenesis. 22 (5): 377–83. doi:10.1002/tcm.10034. PMID 12210501.