MRPL30

39S ribosomal protein L30, mitochondrial is a protein that in humans is encoded by the MRPL30 gene.[5]

MRPL30
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL30, L28MT, L30MT, MRP-L28, MRP-L30, MRPL28, MRPL28M, RPML28, mitochondrial ribosomal protein L30
External IDs	OMIM: 611838 MGI: 1333820 HomoloGene: 32675 GeneCards: MRPL30
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 99,181,152 bp[1] End 99,199,561 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 37,890,477 bp[2] End 37,898,535 bp[2]
Gene ontology Molecular function • structural constituent of ribosome Cellular component • mitochondrial inner membrane • ribosome • large ribosomal subunit • mitochondrial large ribosomal subunit • mitochondrion Biological process • mitochondrial translational elongation • mitochondrial translational termination • protein biosynthesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51263	107734
Ensembl	ENSG00000185414	ENSMUSG00000026087
UniProt	Q8TCC3	Q9D7N6
RefSeq (mRNA)	NM_016503 NM_145212 NM_145213	NM_027098 NM_001356482
RefSeq (protein)	NP_660213	NP_081374 NP_001343411
Location (UCSC)	Chr 2: 99.18 – 99.2 Mb	Chr 1: 37.89 – 37.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified at least two transcript variants encoding the same protein. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000185414 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026087 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MRPL30 mitochondrial ribosomal protein L30".

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Goldschmidt-Reisin S, Kitakawa M, Herfurth E, Wittmann-Liebold B, Grohmann L, Graack HR (December 1998). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences". The Journal of Biological Chemistry. 273 (52): 34828–36. doi:10.1074/jbc.273.52.34828. PMID 9857009.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (September 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8TCC3 (Human 39S ribosomal protein L30, mitochondrial (MRPL30)) at the PDBe-KB.