MRPS33

28S ribosomal protein S33, mitochondrial is a protein that in humans is encoded by the MRPS33 gene.[5][6][7]

MRPS33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS33, MRP-S33, PTD003, S33mt, CGI-139, mitochondrial ribosomal protein S33
External IDs	OMIM: 611993 MGI: 1338046 HomoloGene: 7729 GeneCards: MRPS33
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q34 Start 141,002,610 bp[1] End 141,015,228 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B1|6 Start 39,801,804 bp[2] End 39,810,988 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural constituent of ribosome Cellular component • mitochondrial inner membrane • ribosome • mitochondrion • mitochondrial small ribosomal subunit Biological process • mitochondrial translational elongation • mitochondrial translational termination • protein biosynthesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51650	14548
Ensembl	ENSG00000090263	ENSMUSG00000029918
UniProt	Q9Y291	Q9D2R8
RefSeq (mRNA)	NM_053035 NM_016071	NM_001010930 NM_010270
RefSeq (protein)	NP_057155 NP_444263	NP_001010930 NP_034400
Location (UCSC)	Chr 7: 141 – 141.02 Mb	Chr 6: 39.8 – 39.81 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and Caenorhabditis elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q[7]

References

1. GRCh38: Ensembl release 89: ENSG00000090263 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029918 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
6. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
7. "Entrez Gene: MRPS33 mitochondrial ribosomal protein S33".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.