Phosphomevalonate kinase

Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway[5][6][7] that in humans is encoded by the PMVK gene.

Mevalonate pathway

PMVK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CH4
Identifiers
Aliases	PMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1, phosphomevalonate kinase
External IDs	OMIM: 607622 MGI: 1915853 HomoloGene: 4779 GeneCards: PMVK
EC number	2.7.4.2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 154,924,740 bp[1] End 154,936,719 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 89,454,541 bp[2] End 89,469,013 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • ATP binding • kinase activity • phosphomevalonate kinase activity Cellular component • cytoplasm • cytosol • peroxisome • extracellular exosome • membrane Biological process • cholesterol biosynthetic process • steroid metabolic process • isopentenyl diphosphate biosynthetic process, mevalonate pathway • response to cholesterol • cholesterol metabolic process • sterol biosynthetic process • isoprenoid biosynthetic process • phosphorylation • lipid metabolism • steroid biosynthetic process • regulation of cholesterol biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10654	68603
Ensembl	ENSG00000163344	ENSMUSG00000027952
UniProt	Q15126	Q9D1G2
RefSeq (mRNA)	NM_006556 NM_001323011 NM_001323012 NM_001348696	NM_026784 NM_027348 NM_001310640
RefSeq (protein)	NP_001309940 NP_001309941 NP_006547 NP_001335625	NP_001297569 NP_081060 NP_081624
Location (UCSC)	Chr 1: 154.92 – 154.94 Mb	Chr 3: 89.45 – 89.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphomevalonate kinase
Identifiers
EC number	2.7.4.2
CAS number	9026-46-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Phosphomevalonate kinase
Identifiers
Symbol	PMVK
NCBI gene	10654
HGNC	9141
OMIM	607622
RefSeq	NM_006556
UniProt	Q15126
Other data
EC number	2.7.4.2
Locus	Chr. 1 p13-q23

References

1. GRCh38: Ensembl release 89: ENSG00000163344 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027952 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234: 2595–604. PMID 13801508.
6. Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.
7. Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75: 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.

External links

• Phosphomevalonate+kinase at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q15126 (Phosphomevalonate kinase) at the PDBe-KB.