CDP-diacylglycerol—inositol 3-phosphatidyltransferase
In enzymology, a CDP-diacylglycerol—inositol 3-phosphatidyltransferase (EC 2.7.8.11) is an enzyme that catalyzes the chemical reaction
- CDP-diacylglycerol + myo-inositol CMP + phosphatidyl-1D-myo-inositol
| CDP-diacylglycerol-inositol 3-phosphatidyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.8.11 | ||||||||
| CAS number | 9027-01-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are CDP-diacylglycerol and myo-inositol, whereas its two products are CMP and phosphatidyl-1D-myo-inositol.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase. Other names in common use include CDP-diglyceride-inositol phosphatidyltransferase, phosphatidylinositol synthase, CDP-diacylglycerol-inositol phosphatidyltransferase, CDP-diglyceride:inositol transferase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol, 3-phosphatidyltransferase, CDP-DG:inositol transferase, cytidine diphosphodiglyceride-inositol phosphatidyltransferase, CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase, CDP-diglyceride-inositol transferase, cytidine diphosphoglyceride-inositol phosphatidyltransferase, and cytidine diphosphoglyceride-inositol transferase. This enzyme participates in glycerophospholipid metabolism and phosphatidylinositol signaling system.
References
- Bleasdale JE, Wallis P, MacDonald PC, Johnston JM (1979). "Characterization of the forward and reverse reactions catalyzed by CDP-diacylglycerol:inositol transferase in rabbit lung tissue". Biochim. Biophys. Acta. 575 (1): 135–47. doi:10.1016/0005-2760(79)90139-5. PMID 41587.
- Prottey C, Hawthorne JN (1967). "The biosynthesis of phosphatidic acid and phosphatidylinositol in mammalian pancreas". Biochem. J. 105 (1): 379–92. PMC 1198310. PMID 4293959.
- Salway JG, Harwood JL, Kai M, White GL, Haworne JN (1968). "Enzymes of phosphoinositide metabolism during rat brain development". J. Neurochem. 15 (3): 221–6. doi:10.1111/j.1471-4159.1968.tb06200.x. PMID 4295616.
- Takenawa T, Egawa K (1977). "CDP-diglyceride:inositol transferase from rat liver. Purification and properties". J. Biol. Chem. 252 (15): 5419–23. PMID 18462.