PRIM1

DNA primase small subunit is an enzyme that in humans is encoded by the PRIM1 gene.[5]

PRIM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRIM1, p49, primase (DNA) subunit 1, DNA primase subunit 1
External IDsOMIM: 176635 MGI: 97757 HomoloGene: 730 GeneCards: PRIM1
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.3Start56,731,296 bp[1]
End56,752,374 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5557

19075

Ensembl

ENSG00000198056

ENSMUSG00000025395

UniProt

P49642

P20664

RefSeq (mRNA)

NM_000946

NM_008921

RefSeq (protein)

NP_000937

NP_032947

Location (UCSC)Chr 12: 56.73 – 56.75 MbChr 10: 128.02 – 128.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit.

References

  1. GRCh38: Ensembl release 89: ENSG00000198056 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025395 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics. 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P49642 (Human DNA primase small subunit (PRIM1)) at the PDBe-KB.


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