SULT1A1

Sulfotransferase 1A1 is an enzyme that in humans is encoded by the SULT1A1 gene.[3][4][5]

SULT1A1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1LS6, 1Z28, 2D06, 3QVU, 3QVV, 3U3J, 3U3K, 3U3M, 3U3O, 3U3R, 4GRA
Identifiers
Aliases	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1, sulfotransferase family 1A member 1
External IDs	OMIM: 171150 HomoloGene: 134950 GeneCards: SULT1A1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 28,605,196 bp[1] End 28,623,625 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • sulfotransferase activity • steroid sulfotransferase activity • flavonol 3-sulfotransferase activity • GO:0001948 protein binding • aryl sulfotransferase activity Cellular component • cytoplasm • cytosol Biological process • steroid metabolic process • amine metabolic process • catecholamine metabolic process • estrogen metabolic process • sulfation • lipid metabolism • flavonoid metabolic process • xenobiotic metabolic process • ethanol catabolic process • 3'-phosphoadenosine 5'-phosphosulfate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6817	n/a
Ensembl	ENSG00000196502	n/a
UniProt	P50225	n/a
RefSeq (mRNA)	NM_177536 NM_001055 NM_177529 NM_177530 NM_177534	n/a
RefSeq (protein)	NP_001046 NP_803565 NP_803566 NP_803878 NP_803880	n/a
Location (UCSC)	Chr 16: 28.61 – 28.62 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene.[5]

See also

• Steroid sulfotransferase
• Steroidogenic enzyme

References

1. GRCh38: Ensembl release 89: ENSG00000196502 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Dooley TP, Obermoeller RD, Leiter EH, Chapman HD, Falany CN, Deng Z, Siciliano MJ (Feb 1994). "Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7". Genomics. 18 (2): 440–3. doi:10.1006/geno.1993.1494. PMID 8288252.
4. Dooley TP, Huang Z (Dec 1996). "Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16". Biochem Biophys Res Commun. 228 (1): 134–40. doi:10.1006/bbrc.1996.1628. PMID 8912648.
5. "SULT1A1 sulfotransferase family 1A member 1 [ Homo sapiens (human) ]".

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160.
• Windmill KF, Christiansen A, Teusner JT, et al. (1998). "Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry" (PDF). Chem. Biol. Interact. 109 (1–3): 341–6. doi:10.1016/S0009-2797(97)00144-0. PMID 9566757.
• Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112-113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
• Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
• Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
• Ozawa S, Nagata K, Shimada M, et al. (1995). "Primary structures and properties of two related forms of aryl sulfotransferases in human liver". Pharmacogenetics. 5 Spec No: S135–40. doi:10.1097/00008571-199512001-00015. PMID 7581483.
• Jones AL, Hagen M, Coughtrie MW, et al. (1995). "Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form". Biochem. Biophys. Res. Commun. 208 (2): 855–62. doi:10.1006/bbrc.1995.1414. PMID 7695643.
• Hwang SR, Kohn AB, Hook VY (1995). "Molecular cloning of an isoform of phenol sulfotransferase from human brain hippocampus". Biochem. Biophys. Res. Commun. 207 (2): 701–7. doi:10.1006/bbrc.1995.1244. PMID 7864863.
• Yamazoe Y, Nagata K, Ozawa S, Kato R (1994). "Structural similarity and diversity of sulfotransferases". Chem. Biol. Interact. 92 (1–3): 107–17. doi:10.1016/0009-2797(94)90057-4. PMID 8033246.
• Falany CN, Zhuang W, Falany JL (1994). "Characterization of expressed human phenol-sulfating phenol sulfotransferase: effect of mutating cys70 on activity and thermostability". Chem. Biol. Interact. 92 (1–3): 57–66. doi:10.1016/0009-2797(94)90053-1. PMID 8033270.
• Veronese ME, Burgess W, Zhu X, McManus ME (1994). "Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies". Biochem. J. 302 (2): 497–502. doi:10.1042/bj3020497. PMC 1137255. PMID 8093002.
• Zhu X, Veronese ME, Bernard CC, et al. (1993). "Identification of two human brain aryl sulfotransferase cDNAs". Biochem. Biophys. Res. Commun. 195 (1): 120–7. doi:10.1006/bbrc.1993.2018. PMID 8363592.
• Wilborn TW, Comer KA, Dooley TP, et al. (1993). "Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase". Mol. Pharmacol. 43 (1): 70–7. PMID 8423770.
• Zhu X, Veronese ME, Sansom LN, McManus ME (1993). "Molecular characterisation of a human aryl sulfotransferase cDNA". Biochem. Biophys. Res. Commun. 192 (2): 671–6. doi:10.1006/bbrc.1993.1467. PMID 8484775.
• Her C, Raftogianis R, Weinshilboum RM (1996). "Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization". Genomics. 33 (3): 409–20. doi:10.1006/geno.1996.0216. PMID 8661000.
• Bernier F, Soucy P, Luu-The V (1996). "Human phenol sulfotransferase gene contains two alternative promoters: Structure and expression of the gene". DNA Cell Biol. 15 (5): 367–75. doi:10.1089/dna.1996.15.367. PMID 8924211.
• Raftogianis RB, Her C, Weinshilboum RM (1997). "Human phenol sulfotransferase pharmacogenetics: STP1 gene cloning and structural characterization". Pharmacogenetics. 6 (6): 473–87. doi:10.1097/00008571-199612000-00001. PMID 9014197.