CDP-diacylglycerol—serine O-phosphatidyltransferase
In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase (EC 2.7.8.8) is an enzyme that catalyzes the chemical reaction
- CDP-diacylglycerol + L-serine CMP + (3-sn-phosphatidyl)-L-serine
| CDP-diacylglycerol-serine O-phosphatidyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.8.8 | ||||||||
| CAS number | 9068-48-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are CDP-diacylglycerol and L-serine, whereas its two products are CMP and (3-sn-phosphatidyl)-L-serine.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-diacylglycerol:L-serine 3-sn-phosphatidyltransferase. Other names in common use include phosphatidylserine synthase, CDPdiglyceride-serine O-phosphatidyltransferase, PS synthase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol, (CDPdiglyceride):L-serine O-phosphatidyltransferase, phosphatidylserine synthetase, CDP-diacylglycerol-L-serine O-phosphatidyltransferase, cytidine diphosphoglyceride-serine O-phosphatidyltransferase, CDP-diglyceride-L-serine phosphatidyltransferase, CDP-diglyceride:serine phosphatidyltransferase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine, O-phosphatidyltransferase, and CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism.
References
- Larson TJ, Dowhan W (1976). "Ribosomal-associated phosphatidylserine synthetase from Escherichia coli: purification by substrate-specific elution from phosphocellulose using cytidine 5'-diphospho-1,2-diacyl-sn-glycerol". Biochemistry. 15 (24): 5212–8. doi:10.1021/bi00669a003. PMID 187212.
- Raetz CR, Kennedy EP (1974). "Partial purification and properties of phosphatidylserine synthetase from Escherichia coli". J. Biol. Chem. 249 (16): 5083–45. PMID 4604873.