PAH world hypothesis

The PAH world hypothesis is a speculative hypothesis that proposes that polycyclic aromatic hydrocarbons (PAHs), known to be abundant in the universe,[1][2][3] including in comets,[4] and assumed to be abundant in the primordial soup of the early Earth, played a major role in the origin of life by mediating the synthesis of RNA molecules, leading into the RNA world. However, as yet, the hypothesis is untested.[5]

A PAH stack assembling

Background
The Miller–Urey experiment showed that organic compounds can be readily produced under the presumed conditions of the early Earth

The Miller–Urey experiment in 1952, and others since, demonstrated the synthesis of organic compounds, such as amino acids, formaldehyde and sugars, from the original inorganic precursors the researchers presumed to have been present in the primordial soup (but is no longer considered likely). This experiment inspired many others. In 1961, Joan Oró found that the nucleotide base adenine could be made from hydrogen cyanide (HCN) and ammonia in a water solution.[6] Experiments conducted later showed that the other RNA and DNA nucleobases could be obtained through simulated prebiotic chemistry with a reducing atmosphere.[7]

The RNA world hypothesis shows how RNA can become its own catalyst (a ribozyme). In between there are some missing steps such as how the first RNA molecules could be formed. The PAH world hypothesis was proposed by Simon Nicholas Platts in May 2004 to try to fill in this missing step.[8] A more thoroughly elaborated idea has been published by Ehrenfreund et al.[9]

Polycyclic aromatic hydrocarbons
Main article: Polycyclic aromatic hydrocarbon
The Cat's Paw Nebula lies inside the Milky Way Galaxy and is located in the constellation Scorpius.
Green areas show regions where radiation from hot stars collided with large molecules and small dust grains called "polycyclic aromatic hydrocarbons" (PAHs), causing them to fluoresce.
(Spitzer space telescope, 2018)

Polycyclic aromatic hydrocarbons are the most common and abundant of the known polyatomic molecules in the visible universe, and are considered a likely constituent of the primordial sea.[1][2][3] PAHs, along with fullerenes (or "buckyballs"), have been recently detected in nebulae.[10] In April 2019, scientists, working with the Hubble Space Telescope, reported the confirmed detection of the large and complex ionized molecules of buckminsterfullerene (C60) in the interstellar medium spaces between the stars.[11][12] (Fullerenes are also implicated in the origin of life; according to astronomer Letizia Stanghellini, "It’s possible that buckyballs from outer space provided seeds for life on Earth.”[13]) In September 2012, NASA scientists reported that PAHs, subjected to interstellar medium (ISM) conditions, are transformed, through hydrogenation, oxygenation and hydroxylation, to more complex organics — "a step along the path toward amino acids and nucleotides, the raw materials of proteins and DNA, respectively".[14][15] Further, as a result of these transformations, the PAHs lose their spectroscopic signature which could be one of the reasons "for the lack of PAH detection in interstellar ice grains, particularly the outer regions of cold, dense clouds or the upper molecular layers of protoplanetary disks."[14][15]

On June 6, 2013, scientists at the IAA-CSIC reported the detection of polycyclic aromatic hydrocarbons in the upper atmosphere of Titan, the largest moon of the planet Saturn.[16]

In October 2018, researchers reported low-temperature chemical pathways from simple organic compounds to complex PAHs. Such chemical pathways may help explain the presence of PAHs in the low-temperature atmosphere of Saturn's moon Titan, and may be significant pathways, in terms of the PAH world hypothesis, in producing precursors to biochemicals related to life as we know it.[17][18]

In addition, PAHs are not normally very soluble in sea water, but when subject to ionizing radiation such as solar UV light, the outer hydrogen atoms can be stripped off and replaced with a hydroxyl group, rendering the PAHs far more soluble in water.

These modified PAHs are amphiphilic, which means that they have parts that are both hydrophilic and hydrophobic. When in solution, they assemble in discotic mesogenic (liquid crystal) stacks which, like lipids, tend to organize with their hydrophobic parts protected.

On February 21, 2014, NASA announced a greatly upgraded database[19] for tracking polycyclic aromatic hydrocarbons (PAHs) in the universe. More than 20% of the carbon in the universe may be associated with PAHs,[19][20] possible starting materials for the formation of life. PAHs seem to have been formed as early as a couple of billion years after the Big Bang, are abundant in the universe,[1][2][3] and are associated with new stars and exoplanets.[19]

Attachment of nucleobases to PAH scaffolding

In the self-ordering PAH stack, the separation between adjacent rings is 0.34 nm. This is the same separation found between adjacent nucleotides of RNA and DNA. Smaller molecules will naturally attach themselves to the PAH rings. However PAH rings, while forming, tend to swivel around on one another, which will tend to dislodge attached compounds that would collide with those attached to those above and below. Therefore, it encourages preferential attachment of flat molecules such as pyrimidine and purine nucleobases, the key constituents (and information carriers) of RNA and DNA. These bases are similarly amphiphilic and so also tend to line up in similar stacks.

Attachment of oligomeric backbone

According to the hypothesis, once the nucleobases are attached (via hydrogen bonds) to the PAH scaffolding, the inter-base distance would select for "linker" molecules of a specific size, such as small formaldehyde (methanal) oligomers, also taken from the prebiotic "soup", which will bind (via covalent bonds) to the nucleobases as well as each other to add a flexible structural backbone.[5][8]

Detachment of the RNA-like strands

A subsequent transient drop in the ambient pH (increase in acidity), for example as a result of a volcanic discharge of acidic gases such as sulfur dioxide or carbon dioxide, would allow the bases to break off from their PAH scaffolding, forming RNA-like molecules (with the formaldehyde backbone instead of the ribose-phosphate backbone used by "modern" RNA, but the same 0.34 nm pitch).[5]

Formation of ribozyme-like structures

The hypothesis further speculates that once long RNA-like single strands are detached from the PAH stacks, and after ambient pH levels became less acidic, they would tend to fold back on themselves, with complementary sequences of nucleobases preferentially seeking out each other and forming hydrogen bonds, creating stable, at least partially double-stranded RNA-like structures, similar to ribozymes. The formaldehyde oligomers would eventually be replaced with more stable ribose-phosphate molecules for the backbone material, resulting in a starting milestone for the RNA world hypothesis, which speculates about further evolutionary developments from that point.[5][8][21]

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See also

References
  1. Carey, Bjorn (October 18, 2005). "Life's Building Blocks 'Abundant in Space'". Space.com. Retrieved March 3, 2014.
  2. Hudgins, Douglas M.; Bauschlicher,Jr, Charles W.; Allamandola, L. J. (October 10, 2005). "Variations in the Peak Position of the 6.2 μm Interstellar Emission Feature: A Tracer of N in the Interstellar Polycyclic Aromatic Hydrocarbon Population". Astrophysical Journal. 632 (1): 316–332. Bibcode:2005ApJ...632..316H. CiteSeerX 10.1.1.218.8786. doi:10.1086/432495.
  3. Allamandola, Louis et al. (April 13, 2011). "Cosmic Distribution of Chemical Complexity". NASA. Archived from the original on February 27, 2014. Retrieved March 3, 2014.CS1 maint: uses authors parameter (link)
  4. Clavin, Whitney (February 10, 2015). "Why Comets Are Like Deep Fried Ice Cream". NASA. Retrieved February 10, 2015.
  5. Platts, Simon Nicholas, "The PAH World - Discotic polynuclear aromatic compounds as a mesophase scaffolding at the origin of life"
  6. Oró J, Kimball AP (August 1961). "Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide". Archives of Biochemistry and Biophysics. 94 (2): 217–27. doi:10.1016/0003-9861(61)90033-9. PMID 13731263.
  7. Oró J (1967). Fox SW (ed.). Origins of Prebiological Systems and of Their Molecular Matrices. New York Academic Press. p. 137.
  8. "Prebiotic Molecular Selection and Organization" Archived 2009-05-24 at the Wayback Machine, NASA's Astrobiology website
  9. Ehrenfreund, P; Rasmussen, S; Cleaves, J; Chen, L (2006). "Experimentally tracing the key steps in the origin of life: The aromatic world". Astrobiology. 6 (3): 490–520. Bibcode:2006AsBio...6..490E. doi:10.1089/ast.2006.6.490. PMID 16805704.
  10. García-Hernández, D. A.; Manchado, A.; García-Lario, P.; Stanghellini, L.; Villaver, E.; Shaw, R. A.; Szczerba, R.; Perea-Calderón, J. V. (2010-10-28). "Formation Of Fullerenes In H-Containing Planetary Nebulae". The Astrophysical Journal Letters. 724 (1): L39–L43. arXiv:1009.4357. Bibcode:2010ApJ...724L..39G. doi:10.1088/2041-8205/724/1/L39.
  11. Starr, Michelle (29 April 2019). "The Hubble Space Telescope Has Just Found Solid Evidence of Interstellar Buckyballs". ScienceAlert.com. Retrieved 29 April 2019.
  12. Cordiner, M.A.; et al. (22 April 2019). "Confirming Interstellar C60 + Using the Hubble Space Telescope". The Astrophysical Journal Letters. 875 (2): L28. arXiv:1904.08821. Bibcode:2019ApJ...875L..28C. doi:10.3847/2041-8213/ab14e5.
  13. Atkinson, Nancy (October 27, 2010). "Buckyballs Could Be Plentiful in the Universe". Universe Today. Retrieved October 28, 2010.
  14. Staff (September 20, 2012). "NASA Cooks Up Icy Organics to Mimic Life's Origins". Space.com. Retrieved September 22, 2012.CS1 maint: uses authors parameter (link)
  15. Gudipati, Murthy S.; Yang, Rui (September 1, 2012). "In-Situ Probing Of Radiation-Induced Processing Of Organics In Astrophysical Ice Analogs—Novel Laser Desorption Laser Ionization Time-Of-Flight Mass Spectroscopic Studies". The Astrophysical Journal Letters. 756 (1): L24. Bibcode:2012ApJ...756L..24G. doi:10.1088/2041-8205/756/1/L24.
  16. López-Puertas, Manuel (June 6, 2013). "PAH's in Titan's Upper Atmosphere". CSIC. Retrieved June 6, 2013.
  17. Staff (11 October 2018). ""A Prebiotic Earth" – Missing Link Found on Saturn's Moon Titan". DailyGalaxy.com. Retrieved 11 October 2018.
  18. Zhao, Long; et al. (8 October 2018). "Low-temperature formation of polycyclic aromatic hydrocarbons in Titan's atmosphere". Nature Astronomy. 2 (12): 973–979. Bibcode:2018NatAs...2..973Z. doi:10.1038/s41550-018-0585-y.
  19. Hoover, Rachel (February 21, 2014). "Need to Track Organic Nano-Particles Across the Universe? NASA's Got an App for That". NASA. Retrieved February 22, 2014.
  20. Hoover, Rachel (February 24, 2014). "Online Database Tracks Organic Nano-Particles Across the Universe". Sci Tech Daily. Retrieved March 10, 2015.
  21. Lincoln, Tracey A.; Joyce, Gerald F. (January 8, 2009). "Self-Sustained Replication of an RNA Enzyme". Science. New York: American Association for the Advancement of Science. 323 (5918): 1229–32. Bibcode:2009Sci...323.1229L. doi:10.1126/science.1167856. PMC 2652413. PMID 19131595. Lay summary – Medical News Today (January 12, 2009).
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