EPH receptor A5

EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene.[5][6][7]

EPHA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2R2P, 4ET7
Identifiers
Aliases	EPHA5, CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4, EPH receptor A5
External IDs	OMIM: 600004 MGI: 99654 HomoloGene: 55824 GeneCards: EPHA5
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.1-q13.2 Start 65,319,563 bp[1] End 65,670,495 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E1|5 43.0 cM Start 84,054,761 bp[2] End 84,417,382 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • GPI-linked ephrin receptor activity • transmembrane-ephrin receptor activity • kinase activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • ephrin receptor activity • receptor tyrosine kinase • transmembrane signaling receptor activity Cellular component • integral component of membrane • rough endoplasmic reticulum • cell projection • membrane • cell membrane • integral component of plasma membrane • axon • neuronal cell body • dendrite • perinuclear region of cytoplasm • external side of plasma membrane • cytoplasm • neuron projection • receptor complex Biological process • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of actin cytoskeleton organization • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • neuron development • nervous system development • protein phosphorylation • positive regulation of CREB transcription factor activity • peptidyl-tyrosine phosphorylation • hippocampus development • cAMP-mediated signaling • axon guidance • ephrin receptor signaling pathway • negative regulation of signal transduction • cell differentiation • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2044	13839
Ensembl	ENSG00000145242	ENSMUSG00000029245
UniProt	P54756	Q60629
RefSeq (mRNA)	NM_001281765 NM_001281766 NM_001281767 NM_004439 NM_182472 NM_001318761	NM_007937
RefSeq (protein)	NP_001268694 NP_001268695 NP_001268696 NP_001305690 NP_004430 NP_872272	NP_031963
Location (UCSC)	Chr 4: 65.32 – 65.67 Mb	Chr 5: 84.05 – 84.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000145242 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029245 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
6. Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics. 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.
7. "Entrez Gene: EPHA5 EPH receptor A5".

Further reading

• Zhou R (1997). "Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands". Cell Tissue Res. 290 (2): 251–9. doi:10.1007/s004410050929. PMID 9321686.
• Caras IW (1997). "A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1". Cell Tissue Res. 290 (2): 261–4. doi:10.1007/s004410050930. PMID 9321687.
• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
• Fox GM, Holst PL, Chute HT, et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases". Oncogene. 10 (5): 897–905. PMID 7898931.
• Davis S, Gale NW, Aldrich TH, et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science. 266 (5186): 816–9. doi:10.1126/science.7973638. PMID 7973638.
• Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474.
• Miescher GC, Taylor V, Olivieri G, et al. (1997). "Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors". Brain Res. Mol. Brain Res. 46 (1–2): 17–24. doi:10.1016/S0169-328X(96)00268-9. PMID 9191074.
• Stein E, Savaskan NE, Ninnemann O, et al. (1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting". J. Neurosci. 19 (20): 8885–93. doi:10.1523/JNEUROSCI.19-20-08885.1999. PMID 10516308.