DMPX

DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity to A₂ adenosine receptors, in contrast to the A₁ subtype receptors.[1] DMPX had 28× and 15× higher potency than caffeine in blocking peripheral and central NECA-responses. The locomotor stimulation caused by DMPX (ED₅₀ 10 μmol/kg) was similarly higher than caffeine.[1]

DMPX

Clinical data
ATC code	None
Identifiers
IUPAC name 3,7-Dimethyl-1-(2-propyn-1-yl)-3,7-dihydro-1H-purine-2,6-dione
CAS Number	14114-46-6^Y
PubChem CID	99562
ChemSpider	89948
UNII	5YFR5SPS6T
CompTox Dashboard (EPA)	DTXSID30161577
ECHA InfoCard	100.162.258
Chemical and physical data
Formula	C10H10N4O2
Molar mass	218.216 g·mol^−1
3D model (JSmol)	Interactive image
SMILES Cn2cnc(c2c1=O)n(C)c(=O)n1CC#C
InChI InChI=1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3 Key:IORPOFJLSIHJOG-UHFFFAOYSA-N

See also

• DPCPX
• 8-PT
• CPX (8-CPT)
• 8-Chlorotheophylline
• Theophylline

References

1. Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW (1988). "3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs". Life Sciences. 43 (21): 1671–84. doi:10.1016/0024-3205(88)90478-x. PMID 3193854.