Uridine triphosphate

Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate, consisting of the organic base uracil linked to the 1' carbon of the ribose sugar, and esterified with tri-phosphoric acid at the 5' position. Its main role is as substrate for the synthesis of RNA during transcription. UTP is the precursor for the production of CTP via the help of CTP Synthetase.[1] UTP can be biosynthesized from UDP by Nucleoside Diphosphate Kinase after using phosphate group from ATP.[2][3] UDP + ATP ⇌ UTP + ADP[4]; both UTP and ATP are energetically equal[4]

Uridine triphosphate
Names
IUPAC name
[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan- 2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
Identifiers
ChEMBL
ECHA InfoCard 100.000.508
MeSH Uridine+triphosphate
UNII
Properties
C9H15N2O15P3
Molar mass 484.141
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Role in metabolism

UTP also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of ATP, but more specific. When UTP activates a substrate (like Glucose-1-phosphate), UDP-glucose is formed and inorganic phosphate is released.[5] UDP-glucose enters the synthesis of glycogen. UTP is used in the metabolism of galactose, where the activated form UDP-galactose is converted to UDP-glucose. UDP-glucuronate is used to conjugate bilirubin to a more water-soluble bilirubin diglucuronide. UTP is also used to activate amino sugars like Glucosamine-1-phosphate to UDP-glucosamine, and N-acetyl-glucosamine-1-phosphate to UDP-N-acetylglucosamine.[6]

Role in receptor mediation

UTP also has roles in mediating responses by extracellular binding to the P2Y receptors of cells. UTP and its derivatives are still being investigated for their applications in human medicine.

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See also
  • CTP synthase

References
  1. Meisenberg, Gerhard Meisenberg (2017). Principles of Medical Biochemistry. Philadelphia, PA, USA: Elsevier. p. 505. ISBN 978-0-323-29616-8.
  2. Victor, Rodwell (2015). Haper's illustrated Biochemistry. USA: McGraw-Hill. p. 118. ISBN 978-0-07-182537-5.
  3. Meisenberg, Gerhard Meisenberg (2017). Principles of MEDICAL BIOCHEMISTRY, 4th edition. Philadelphia, PA, USA: Elsevier. p. 59. ISBN 978-0-323-29616-8.
  4. Voet, Donald (2011). Biochemistry, 4th edition. USA: JOHN WILEY & SONS, INC. p. 645. ISBN 978-0470-57095-1.
  5. Rodwell, Victor (2015). Harper's illustrated Biochemistry. USA: McGraw-Hill. p. 176. ISBN 978-0-07-182537-5.
  6. Rodwell, Victor (2015). Harper's illustrated biochemistry, 13th edition. USA: McGraw-Hill. p. 204. ISBN 978-0-07-182537-5.


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