Dichloropane
Dichloropane ((−)-2β-Carbomethoxy-3β-(3,4-dichlorophenyl)tropane, RTI-111, O-401) is a stimulant of the phenyltropane class that acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 3.13, 0.79 and 18 nM, respectively.[1] In animal studies, dichloropane had a slower onset and longer duration of action compared to cocaine.[2][3]
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| Formula | C15H17Cl2NO2 |
| Molar mass | 314.21 g·mol−1 |
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Methylecgonidine is the direct precursor to this compound.[4]
Trans -CO2Me group
The thermodynamic isomer with a trans -CO2Me group is still active. This isomer was used by Neurosearch to make three different phenyltropanes which were tested in clinical trials.
- Tesofensine
- Brasofensine
- NS-2359 (GSK-372,475)
gollark: - They may be working on them, but they initially claimed that they weren't necessary and they don't exist now. Also, I don't trust them to not do them wrong.- Ooookay then- Well, generics, for one: they *kind of exist* in that you can have generic maps, channels, slices, and arrays, but not anything else. Also this (https://fasterthanli.me/blog/2020/i-want-off-mr-golangs-wild-ride/), which is mostly about the file handling not being good since it tries to map on concepts which don't fit. Also channels having weird special syntax. Also `for` and `range` and `new` and `make` basically just being magic stuff which do whatever the compiler writers wanted with no consistency- see above- Because there's no generic number/comparable thing type. You would need to use `interface{}` or write a new function (with identical code) for every type you wanted to compare- You can change a signature somewhere and won't be alerted, but something else will break because the interface is no longer implemented- They are byte sequences. https://blog.golang.org/strings.- It's not. You need to put `if err != nil { return err }` everywhere.
gollark: Oh, and the error handling is terrible and it's kind of the type system's fault.
gollark: If I remember right Go strings are just byte sequences with no guarantee of being valid UTF-8, but all the functions working on them just assume they are.
gollark: Oh, and the strings are terrible.
gollark: Also, channels are not a particularly good primitive for synchronization.
References
- Carroll FI, Blough BE, Nie Z, Kuhar MJ, Howell LL, Navarro HA (April 2005). "Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters". Journal of Medicinal Chemistry. 48 (8): 2767–71. doi:10.1021/jm040185a. PMID 15828814.
- Ranaldi R, Anderson KG, Carroll FI, Woolverton WL (December 2000). "Reinforcing and discriminative stimulus effects of RTI 111, a 3-phenyltropane analog, in rhesus monkeys: interaction with methamphetamine". Psychopharmacology. 153 (1): 103–10. doi:10.1007/s002130000602. PMID 11255920.
- Cook CD, Carroll IF, Beardsley PM (December 2001). "Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat". Psychopharmacology. 159 (1): 58–63. doi:10.1007/s002130100891. PMID 11797070.
- Carroll FI, Mascarella SW, Kuzemko MA, Gao Y, Abraham P, Lewin AH, et al. (September 1994). "Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters". Journal of Medicinal Chemistry. 37 (18): 2865–73. doi:10.1021/jm00044a007. PMID 8071935.
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