Casein kinase 1, alpha 1

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.[5]

CSNK1A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FQD
Identifiers
Aliases	CSNK1A1, CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975, casein kinase 1 alpha 1
External IDs	OMIM: 600505 MGI: 1934950 HomoloGene: 111694 GeneCards: CSNK1A1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 149,492,982 bp[1] End 149,551,471 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1 Start 61,555,274 bp[2] End 61,590,061 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • GO:0001948 protein binding • ATP binding • kinase activity • protein serine/threonine kinase activity Cellular component • cytoplasm • condensed chromosome kinetochore • centrosome • nuclear speck • mRNA cleavage and polyadenylation specificity factor complex • membrane • keratin filament • chromosome • microtubule organizing center • chromosome, centromeric region • cytoskeleton • beta-catenin destruction complex • kinetochore • cell nucleus • cytosol • cilium • cell projection • ciliary basal body • ribonucleoprotein Biological process • regulation of GTP binding • Golgi organization • phosphorylation • cell division • protein phosphorylation • cell surface receptor signaling pathway • peptidyl-serine phosphorylation • phagocytosis • intermediate filament cytoskeleton organization • cell cycle • negative regulation of canonical Wnt signaling pathway • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • signal transduction • proteasome-mediated ubiquitin-dependent protein catabolic process • beta-catenin destruction complex assembly • regulation of cell shape • beta-catenin destruction complex disassembly • Wnt signaling pathway • cell morphogenesis • peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1452	93687
Ensembl	ENSG00000113712	ENSMUSG00000024576
UniProt	P48729	Q6PJ87
RefSeq (mRNA)	NM_001025105 NM_001271741 NM_001271742 NM_001892	NM_146087 NM_001357498 NM_001357499 NM_001357500
RefSeq (protein)	NP_001020276 NP_001258670 NP_001258671 NP_001883	NP_666199 NP_001344427 NP_001344428 NP_001344429
Location (UCSC)	Chr 5: 149.49 – 149.55 Mb	Chr 18: 61.56 – 61.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Casein kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1[6][7] and AXIN1.[8]

See also

• Casein kinase 1

References

1. GRCh38: Ensembl release 89: ENSG00000113712 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024576 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tapia C, Featherstone T, Gómez C, Taillon-Miller P, Allende CC, Allende JE (Aug 1994). "Cloning and chromosomal localization of the gene coding for human protein kinase CK1". FEBS Letters. 349 (2): 307–12. doi:10.1016/0014-5793(94)00679-2. PMID 8050587.
6. Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430.
7. Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A (Jun 2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry. 276 (22): 18757–64. doi:10.1074/jbc.M010005200. PMID 11278595.
8. Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.

Further reading

• Veis A, Sfeir C, Wu CB (1998). "Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity". Critical Reviews in Oral Biology and Medicine. 8 (4): 360–79. doi:10.1177/10454411970080040101. PMID 9391750.
• Giaccia AJ, Kastan MB (Oct 1998). "The complexity of p53 modulation: emerging patterns from divergent signals". Genes & Development. 12 (19): 2973–83. doi:10.1101/gad.12.19.2973. PMID 9765199.