Casein kinase 1, alpha 1

CSNK1A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5FQD
Identifiers
Aliases	CSNK1A1, CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975, casein kinase 1 alpha 1
External IDs	OMIM: 600505 MGI: 1934950 HomoloGene: 111694 GeneCards: CSNK1A1
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	149,551,471 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	61,590,061 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • protein kinase activity; • nucleotide binding; • GO:0001948 protein binding; • ATP binding; • kinase activity; • protein serine/threonine kinase activity;
Cellular component	• cytoplasm; • condensed chromosome kinetochore; • centrosome; • nuclear speck; • mRNA cleavage and polyadenylation specificity factor complex; • membrane; • keratin filament; • chromosome; • microtubule organizing center; • chromosome, centromeric region; • cytoskeleton; • beta-catenin destruction complex; • kinetochore; • cell nucleus; • cytosol; • cilium; • cell projection; • ciliary basal body; • ribonucleoprotein;
Biological process	• regulation of GTP binding; • Golgi organization; • phosphorylation; • cell division; • protein phosphorylation; • cell surface receptor signaling pathway; • peptidyl-serine phosphorylation; • phagocytosis; • intermediate filament cytoskeleton organization; • cell cycle; • negative regulation of canonical Wnt signaling pathway; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • signal transduction; • proteasome-mediated ubiquitin-dependent protein catabolic process; • beta-catenin destruction complex assembly; • regulation of cell shape; • beta-catenin destruction complex disassembly; • Wnt signaling pathway; • cell morphogenesis; • peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	1452
	93687
	ENSG00000113712
	ENSMUSG00000024576
	P48729
	Q6PJ87
	NM_001025105; NM_001271741; NM_001271742; NM_001892
	NM_146087; NM_001357498; NM_001357499; NM_001357500
	NP_001020276; NP_001258670; NP_001258671; NP_001883
	NP_666199; NP_001344427; NP_001344428; NP_001344429
	Wikidata
View/Edit Human	View/Edit Mouse

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.[5]

Interactions

Casein kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1[6][7] and AXIN1.[8]

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gollark: Ah, applied principle of explosion.

gollark: And both seem like a reasonable response to "people will be eternally tortured if they do not do this".

gollark: I don't *agree* with religious evangelism, I'm saying that it does not seem inconsistent with "true Catholicism" as qh4os says.

References

GRCh38: Ensembl release 89: ENSG00000113712 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024576 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tapia C, Featherstone T, Gómez C, Taillon-Miller P, Allende CC, Allende JE (Aug 1994). "Cloning and chromosomal localization of the gene coding for human protein kinase CK1". FEBS Letters. 349 (2): 307–12. doi:10.1016/0014-5793(94)00679-2. PMID 8050587.
Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430.
Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A (Jun 2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry. 276 (22): 18757–64. doi:10.1074/jbc.M010005200. PMID 11278595.
Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.

Casein kinase 1, alpha 1

Interactions

See also

References

Further reading