CP-94253

CP-94253 is a drug which acts as a potent and selective serotonin 5-HT_1B receptor agonist, with approximately 25x and 40x selectivity over the closely related 5-HT_1D and 5-HT_1A receptors.[1] It has a range of behavioral effects, based on animal testing. The effects include the following: promoting wakefulness by increasing dopamine release in the brain;[2][3] reducing food intake and promoting satiety;[4][5][6] enhancing the reinforcing effects of cocaine;[7][8][9][10] and possible antidepressant effects.[11]

CP-94253

Identifiers
IUPAC name 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine
CAS Number	131084-35-0^Y
PubChem CID	4029677
IUPHAR/BPS	3221
ChemSpider	3246572^N
CompTox Dashboard (EPA)	DTXSID10470073
Chemical and physical data
Formula	C15H19N3O
Molar mass	257.337 g·mol^−1
3D model (JSmol)	Interactive image
SMILES c13nc(OCCC)ccc1[nH]cc3C2=CCNCC2
InChI InChI=1S/C15H19N3O/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11/h3-5,10,16-17H,2,6-9H2,1H3^N Key:KWQWBZIGHIOKIO-UHFFFAOYSA-N^N
^NY (what is this?)  (verify)

References

1. Koe KB, Nielsen JA, Macor JE, Heym J (1992). "Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253". Drug Development Research. 26 (3): 241–250. doi:10.1002/ddr.430260305.
2. Monti JM, Monti D, Jantos H, Ponzoni A (Dec 1995). "Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat". Neuropharmacology. 34 (12): 1647–51. doi:10.1016/0028-3908(95)00112-3. PMID 8788962.
3. Iyer RN, Bradberry CW (Apr 1996). "Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization". Journal of Pharmacology and Experimental Therapeutics. 277 (1): 40–7. PMID 8613947.
4. Halford JC, Blundell JE (Sep 1996). "The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence". Physiology & Behavior. 60 (3): 933–9. doi:10.1016/0031-9384(96)00073-x. PMID 8873272.
5. Lee MD, Simansky KJ (Jun 1997). "CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety". Psychopharmacology. 131 (3): 264–70. doi:10.1007/s002130050292. PMID 9203237.
6. Lee MD, Kennett GA, Dourish CT, Clifton PG (October 2002). "5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253". Psychopharmacology (Berl.). 164 (1): 49–60. doi:10.1007/s00213-002-1162-7. PMID 12373419.
7. Parsons LH, Weiss F, Koob GF (Dec 1998). "Serotonin1B receptor stimulation enhances cocaine reinforcement". Journal of Neuroscience. 18 (23): 10078–89. PMID 9822762.
8. Przegalinski E, Filip M, Papla I, Siwanowicz J (Apr 2001). "Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats". Behavioural Pharmacology. 12 (2): 109–16. doi:10.1097/00008877-200104000-00004. PMID 11396515.
9. Przegaliński E, Gołda A, Frankowska M, Zaniewska M, Filip M (March 2007). "Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats". European Journal of Pharmacology. 559 (2–3): 165–72. doi:10.1016/j.ejphar.2006.12.012. PMID 17291490.
10. Przegaliński E, Gołda A, Filip M (2008). "Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats". Pharmacological Reports : PR. 60 (6): 798–810. PMID 19211971.
11. Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E (May 2005). "Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action". European Journal of Pharmacology. 516 (1): 46–50. doi:10.1016/j.ejphar.2005.04.025. PMID 15913599.