60S ribosomal protein L18

60S ribosomal protein L18 is a protein that in humans is encoded by the RPL18 gene.[5][6]

RPL18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL18, L18, ribosomal protein L18, DBA18
External IDs	OMIM: 604179 MGI: 98003 HomoloGene: 756 GeneCards: RPL18
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,615,328 bp[1] End 48,619,184 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,715,457 bp[2] End 45,720,836 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA binding • structural constituent of ribosome Cellular component • ribosome • membrane • focal adhesion • intracellular • nucleolus • cytosolic large ribosomal subunit • cell nucleus • cytoplasm • endoplasmic reticulum • cytosol • rough endoplasmic reticulum • polysomal ribosome Biological process • viral transcription • SRP-dependent cotranslational protein targeting to membrane • translational initiation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • rRNA processing • protein biosynthesis • cytoplasmic translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6141	19899
Ensembl	ENSG00000063177	ENSMUSG00000059070
UniProt	Q07020	P35980
RefSeq (mRNA)	NM_000979 NM_001270490	NM_009077
RefSeq (protein)	NP_000970 NP_001257419	NP_033103
Location (UCSC)	Chr 19: 48.62 – 48.62 Mb	Chr 7: 45.72 – 45.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000063177 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059070 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puder M, Barnard GF, Staniunas RJ, Steele GD Jr, Chen LB (Dec 1993). "Nucleotide and deduced amino acid sequence of human ribosomal protein L18". Biochim Biophys Acta. 1216 (1): 134–6. doi:10.1016/0167-4781(93)90050-n. PMID 8218404.
6. "Entrez Gene: RPL18 ribosomal protein L18".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325.
• Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Kullberg M, Nilsson MA, Arnason U, et al. (2006). "Housekeeping genes for phylogenetic analysis of eutherian relationships". Mol. Biol. Evol. 23 (8): 1493–503. doi:10.1093/molbev/msl027. PMID 16751257.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.