60S ribosomal protein L10

60S ribosomal protein L10 is a protein that in humans is encoded by the RPL10 gene.[5][6]

RPL10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PA2, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL10, AUTSX5, DXS648, DXS648E, L10, NOV, QM, ribosomal protein L10, MRXS35
External IDs	OMIM: 312173 MGI: 105943 HomoloGene: 130545 GeneCards: RPL10
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 154,389,955 bp[1] End 154,409,168 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 37.94 cM Start 74,270,812 bp[2] End 74,273,135 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • RNA binding • structural constituent of ribosome • translation regulator activity Cellular component • cytosol • ribosome • membrane • intracellular • endoplasmic reticulum • cytosolic large ribosomal subunit • cell nucleus • smooth endoplasmic reticulum • macromolecular complex Biological process • viral transcription • SRP-dependent cotranslational protein targeting to membrane • ribosomal large subunit assembly • translational initiation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • protein biosynthesis • rRNA processing • negative regulation of transcription from RNA polymerase II promoter • negative regulation of apoptotic process • regulation of translation • embryonic brain development • multicellular organism development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6134	110954
Ensembl	ENSG00000147403	ENSMUSG00000008682
UniProt	P27635	Q6ZWV3
RefSeq (mRNA)	NM_006013 NM_001256577 NM_001256580 NM_001303624 NM_001303625 NM_001303626	NM_052835
RefSeq (protein)	NP_001243506 NP_001243509 NP_001290553 NP_001290554 NP_001290555 NP_006004	NP_443067
Location (UCSC)	Chr X: 154.39 – 154.41 Mb	Chr X: 74.27 – 74.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

Interactions

RPL10 has been shown to interact with YES1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000147403 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008682 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
6. "Entrez Gene: RPL10 ribosomal protein L10".
7. Oh HS, Kwon H, Sun SK, Yang CH (September 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. 277 (39): 36489–98. doi:10.1074/jbc.M201859200. PMID 12138090.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• van den Ouweland AM, Kioschis P, Verdijk M, Tamanini F, Toniolo D, Poustka A, van Oost BA (1993). "Identification and characterization of a new gene in the human Xq28 region". Hum. Mol. Genet. 1 (4): 269–73. doi:10.1093/hmg/1.4.269. PMID 1303197.
• van den Ouweland AM, Verdijk M, Mannens MM, van Oost BA (1992). "The QM gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor". Hum. Genet. 90 (1–2): 144–6. doi:10.1007/bf00210759. PMID 1330878.
• Kaneko K, Kobayashi H, Onodera O, Miyatake T, Tsuji S (1993). "Genomic organization of a cDNA (QM) demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells and its localization to Xq28". Hum. Mol. Genet. 1 (7): 529–33. doi:10.1093/hmg/1.7.529. PMID 1339145.
• Bignon C, Roux-Dosseto M, Zeigler ME, Wicha MS, Martin PM (1992). "cDNA cloning and genomic analysis of a new multigene family sharing common phylogenetic and expression profiles with the laminin receptor gene". Biochem. Biophys. Res. Commun. 184 (3): 1165–72. doi:10.1016/S0006-291X(05)80005-1. PMID 1534224.
• Dowdy SF, Lai KM, Weissman BE, Matsui Y, Hogan BL, Stanbridge EJ (1991). "The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells". Nucleic Acids Res. 19 (20): 5763–9. doi:10.1093/nar/19.20.5763. PMC 328988. PMID 1658743.
• Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Farmer AA, Johnsen JI, Loftus TM, Smith KP, Stanbridge EJ (1996). "Isolation and characterization of the QM promoter". Nucleic Acids Res. 24 (11): 2158–65. doi:10.1093/nar/24.11.2158. PMC 145915. PMID 8668549.
• Chen EY, Zollo M, Mazzarella R, Ciccodicola A, Chen CN, Zuo L, Heiner C, Burough F, Repetto M, Schlessinger D, D'Urso M (1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum. Mol. Genet. 5 (5): 659–68. doi:10.1093/hmg/5.5.659. PMID 8733135.
• Chan YL, Diaz JJ, Denoroy L, Madjar JJ, Wool IG (1996). "The primary structure of rat ribosomal protein L10: relationship to a Jun-binding protein and to a putative Wilms' tumor suppressor". Biochem. Biophys. Res. Commun. 225 (3): 952–6. doi:10.1006/bbrc.1996.1277. PMID 8780716.
• Inada H, Mukai J, Matsushima S, Tanaka T (1997). "QM is a novel zinc-binding transcription regulatory protein: its binding to c-Jun is regulated by zinc ions and phosphorylation by protein kinase C". Biochem. Biophys. Res. Commun. 230 (2): 331–4. doi:10.1006/bbrc.1996.5955. PMID 9016777.
• Loftus TM, Nguyen YH, Stanbridge EJ (1997). "The QM protein associates with ribosomes in the rough endoplasmic reticulum". Biochemistry. 36 (27): 8224–30. doi:10.1021/bi970288d. PMID 9204867.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nguyen YH, Mills AA, Stanbridge EJ (1998). "Assembly of the QM protein onto the 60S ribosomal subunit occurs in the cytoplasm". J. Cell. Biochem. 68 (2): 281–5. doi:10.1002/(SICI)1097-4644(19980201)68:2<281::AID-JCB14>3.0.CO;2-I. PMID 9443083.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.