60S ribosomal protein L10

60S ribosomal protein L10 is a protein that in humans is encoded by the RPL10 gene.[5][6]

RPL10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPL10, AUTSX5, DXS648, DXS648E, L10, NOV, QM, ribosomal protein L10, MRXS35
External IDsOMIM: 312173 MGI: 105943 HomoloGene: 130545 GeneCards: RPL10
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq28Start154,389,955 bp[1]
End154,409,168 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

6134

110954

Ensembl

ENSG00000147403

ENSMUSG00000008682

UniProt

P27635

Q6ZWV3

RefSeq (mRNA)

NM_052835

RefSeq (protein)

NP_443067

Location (UCSC)Chr X: 154.39 – 154.41 MbChr X: 74.27 – 74.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

Interactions

RPL10 has been shown to interact with YES1.[7]

gollark: It *continues* doing that until the ring is entirely offscreen.
gollark: It moves outward from that in concentric square "rings", and sets each pixel in that to a randomly selected adjacent pixel plus some random adjustments.
gollark: It picks a "seed color" and puts it in a random location of the output image.
gollark: I learned vaguely how it worked from porting and then debugging it a ton, so:
gollark: Well, it's a port of a Haskell program, hence the name `fractalart-rs`, but running much faster, which is important as the algorithm is O(n³) or something.

References
  1. GRCh38: Ensembl release 89: ENSG00000147403 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000008682 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  6. "Entrez Gene: RPL10 ribosomal protein L10".
  7. Oh HS, Kwon H, Sun SK, Yang CH (September 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. 277 (39): 36489–98. doi:10.1074/jbc.M201859200. PMID 12138090.

Further reading
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