UBE2V1

Ubiquitin-conjugating enzyme E2 variant 1 is a protein that in humans is encoded by the UBE2V1 gene.[5][6][7]

UBE2V1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A4D, 2C2V, 2HLW
Identifiers
Aliases	UBE2V1, CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A, ubiquitin conjugating enzyme E2 V1
External IDs	OMIM: 602995 MGI: 1913839 HomoloGene: 81888 GeneCards: UBE2V1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 50,081,124 bp[1] End 50,115,959 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 87.44 cM Start 167,607,638 bp[2] End 167,632,095 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • ubiquitin protein ligase binding • ubiquitin conjugating enzyme activity Cellular component • cytoplasm • cytosol • ubiquitin conjugating enzyme complex • UBC13-UEV1A complex • ubiquitin ligase complex • extracellular exosome • cell nucleus • nucleoplasm • macromolecular complex Biological process • protein polyubiquitination • Fc-epsilon receptor signaling pathway • protein K63-linked ubiquitination • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of transcription, DNA-templated • stimulatory C-type lectin receptor signaling pathway • regulation of DNA repair • regulation of transcription, DNA-templated • T cell receptor signaling pathway • cell differentiation • postreplication repair • positive regulation of I-kappaB kinase/NF-kappaB signaling • activation of MAPK activity • JNK cascade • positive regulation of NF-kappaB transcription factor activity • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7335	66589
Ensembl	ENSG00000244687	ENSMUSG00000078923
UniProt	Q13404	Q9CZY3
RefSeq (mRNA)	NM_001032288 NM_001257393 NM_001257394 NM_001257395 NM_001257396 NM_001257397 NM_001257398 NM_001257399 NM_001282575 NM_001282576 NM_001282577 NM_001282578 NM_001282579 NM_001282580 NM_021988 NM_022442 NM_199144	NM_023230 NM_001311131 NM_001311146
RefSeq (protein)	NP_001027459 NP_001244322 NP_001244323 NP_001244324 NP_001244325 NP_001244326 NP_001244327 NP_001244328 NP_001269504 NP_001269505 NP_001269506 NP_001269507 NP_001269508 NP_001269509 NP_068823 NP_071887 NP_954595 NP_954673	NP_001298060 NP_001298075 NP_075719
Location (UCSC)	Chr 20: 50.08 – 50.12 Mb	Chr 2: 167.61 – 167.63 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. A pseudogene has been identified which is also located on chromosome 20. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.[7]

Interactions

UBE2V1 has been shown to interact with UBE2N.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000244687 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078923 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sancho E, Vilá MR, Sánchez-Pulido L, Lozano JJ, Paciucci R, Nadal M, Fox M, Harvey C, Bercovich B, Loukili N, Ciechanover A, Lin SL, Sanz F, Estivill X, Valencia A, Thomson TM (January 1998). "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells". Mol Cell Biol. 18 (1): 576–89. doi:10.1128/mcb.18.1.576. PMC 121525. PMID 9418904.
6. Rothofsky ML, Lin SL (October 1997). "CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter". Gene. 195 (2): 141–9. doi:10.1016/S0378-1119(97)00097-8. PMID 9305758.
7. "Entrez Gene: UBE2V1 ubiquitin-conjugating enzyme E2 variant 1".
8. Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ (October 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain". Cell. 103 (2): 351–61. doi:10.1016/S0092-8674(00)00126-4. PMID 11057907.

Further reading

• Long M (2001). "A new function evolved from gene fusion". Genome Res. 10 (11): 1655–7. doi:10.1101/gr.165700. PMID 11076848.
• Thomson TM, Khalid H, Lozano JJ, Sancho E, Ariño J (1998). "Role of UEV-1A, a homologue of the tumor suppressor protein TSG101, in protection from DNA damage". FEBS Lett. 423 (1): 49–52. doi:10.1016/S0014-5793(98)00060-X. PMID 9580084.
• Xiao W, Lin SL, Broomfield S, Chow BL, Wei YF (1998). "The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family". Nucleic Acids Res. 26 (17): 3908–14. doi:10.1093/nar/26.17.3908. PMC 147796. PMID 9705497.
• Ma L, Broomfield S, Lavery C, Lin SL, Xiao W, Bacchetti S (1998). "Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines". Oncogene. 17 (10): 1321–6. doi:10.1038/sj.onc.1202058. PMID 9771976.
• Hofmann RM, Pickart CM (1999). "Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair". Cell. 96 (5): 645–53. doi:10.1016/S0092-8674(00)80575-9. PMID 10089880.
• Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ (2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain". Cell. 103 (2): 351–61. doi:10.1016/S0092-8674(00)00126-4. PMID 11057907.
• Thomson TM, Lozano JJ, Loukili N, Carrió R, Serras F, Cormand B, Valeri M, Díaz VM, Abril J, Burset M, Merino J, Macaya A, Corominas M, Guigó R (2001). "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene". Genome Res. 10 (11): 1743–56. doi:10.1101/gr.GR-1405R. PMC 310942. PMID 11076860.
• Ito M, Shichijo S, Tsuda N, Ochi M, Harashima N, Saito N, Itoh K (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells". Cancer Res. 61 (5): 2038–46. PMID 11280764.
• Andersen PL, Zhou H, Pastushok L, Moraes T, McKenna S, Ziola B, Ellison MJ, Dixit VM, Xiao W (2005). "Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A". J. Cell Biol. 170 (5): 745–55. doi:10.1083/jcb.200502113. PMC 2171356. PMID 16129784.
• Hau DD, Lewis MJ, Saltibus LF, Pastushok L, Xiao W, Spyracopoulos L (2006). "Structure and interactions of the ubiquitin-conjugating enzyme variant human Uev1a: implications for enzymatic synthesis of polyubiquitin chains". Biochemistry. 45 (32): 9866–77. doi:10.1021/bi060631r. PMID 16893187.
• Syed NA, Andersen PL, Warrington RC, Xiao W (2007). "Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-kappaB activation". Apoptosis. 11 (12): 2147–57. doi:10.1007/s10495-006-0197-3. PMID 17041755.
• Petroski MD, Zhou X, Dong G, Daniel-Issakani S, Payan DG, Huang J (2007). "Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme". J. Biol. Chem. 282 (41): 29936–45. doi:10.1074/jbc.M703911200. PMID 17709375.