TRAP1

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.[5][6][7]

TRAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRAP1, HSP 75, HSP75, HSP90L, TRAP-1, TNF receptor associated protein 1
External IDsOMIM: 606219 MGI: 1915265 HomoloGene: 9457 GeneCards: TRAP1
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p13.3Start3,651,639 bp[1]
End3,717,553 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10131

68015

Ensembl

ENSG00000126602

ENSMUSG00000005981

UniProt

Q12931

Q9CQN1

RefSeq (mRNA)

NM_001272049
NM_016292

NM_026508

RefSeq (protein)

NP_001258978
NP_057376

NP_080784

Location (UCSC)Chr 16: 3.65 – 3.72 MbChr 16: 4.04 – 4.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

TRAP1 has been shown to interact with EXT2,[8] EXT1[8] and Retinoblastoma protein.[9]

gollark: It doesn't.
gollark: Er, that might work, I'll test it.
gollark: <@111608748027445248> remove it how?
gollark: - Signed disks are autorunned upon being inserted- Lua code sent over the potatOS command websocket is executed with privileged access- The autoupdater can autoupdate to anything (*is* this a backdoor?)
gollark: It performs no useful function but is very hard to remove (without *CHEATING* by putting it in another computer's disk drive), contains lovely backdoors, has useless bundled software, and autoupdates, even to broken versions.In short, it's Windows, which seems to be quite popular.

References

  1. GRCh38: Ensembl release 89: ENSG00000126602 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000005981 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties". J Biol Chem. 275 (5): 3305–12. doi:10.1074/jbc.275.5.3305. PMID 10652318.
  6. Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB (March 1995). "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor". J Biol Chem. 270 (8): 3574–81. doi:10.1074/jbc.270.8.3574. PMID 7876093.
  7. "Entrez Gene: TRAP1 TNF receptor-associated protein 1".
  8. Simmons, A D; Musy M M; Lopes C S; Hwang L Y; Yang Y P; Lovett M (November 1999). "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses". Hum. Mol. Genet. 8 (12): 2155–64. doi:10.1093/hmg/8.12.2155. ISSN 0964-6906. PMID 10545594.
  9. Chen, C F; Chen Y; Dai K; Chen P L; Riley D J; Lee W H (September 1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock". Mol. Cell. Biol. 16 (9): 4691–9. doi:10.1128/MCB.16.9.4691. ISSN 0270-7306. PMC 231469. PMID 8756626.

Further reading


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