UBL5

Ubiquitin-like protein 5 is a protein that in humans is encoded by the UBL5 gene.[5]

UBL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P0R, 4PYU
Identifiers
Aliases	UBL5, HUB1, ubiquitin like 5
External IDs	OMIM: 606849 MGI: 1913427 HomoloGene: 83305 GeneCards: UBL5
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 9,827,892 bp[1] End 9,830,115 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A3 Start 20,642,878 bp[2] End 20,647,140 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein tag Cellular component • cytoplasm • cell nucleus Biological process • mRNA splicing, via spliceosome • cellular protein modification process • positive regulation of protein targeting to mitochondrion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	59286	66177
Ensembl	ENSG00000198258	ENSMUSG00000084786
UniProt	Q9BZL1	Q9EPV8
RefSeq (mRNA)	NM_024292 NM_001048241	NM_025401 NM_001310746
RefSeq (protein)	NP_001041706 NP_077268 NP_001041706.1 NP_077268.1	NP_001297675 NP_079677 NP_001347954 NP_001347955 NP_001347956
Location (UCSC)	Chr 19: 9.83 – 9.83 Mb	Chr 9: 20.64 – 20.65 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

It has been shown that in C. elegans mitochondria treated to lower expression of certain electron transport chain proteins during the L3/L4 stage, its expression levels is higher leading to increased lifespans.[6]

Ubiquitin-like proteins (UBLs) are thought to be reversible modulators of protein function rather than protein degraders like ubiquitin (MIM 191339).[supplied by OMIM][5]

References

1. GRCh38: Ensembl release 89: ENSG00000198258 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000084786 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: UBL5 ubiquitin-like 5".
6. Mitochondrial Stress Signals Revise an Old Aging Theory - DOI 10.1016/j.cell.2010.12.023

Further reading

• Friedman JS, Koop BF, Raymond V, Walter MA (2001). "Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes". Genomics. 71 (2): 252–5. doi:10.1006/geno.2000.6439. PMID 11161819.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kantham L, Kerr-Bayles L, Godde N, et al. (2003). "Beacon interacts with cdc2/cdc28-like kinases". Biochem. Biophys. Res. Commun. 304 (1): 125–9. doi:10.1016/S0006-291X(03)00549-7. PMID 12705895.
• McNally T, Huang Q, Janis RS, et al. (2004). "Structural analysis of UBL5, a novel ubiquitin-like modifier". Protein Sci. 12 (7): 1562–6. doi:10.1110/ps.0382803. PMC 2323916. PMID 12824502.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wilkinson CR, Dittmar GA, Ohi MD, et al. (2005). "Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast". Curr. Biol. 14 (24): 2283–8. doi:10.1016/j.cub.2004.11.058. PMID 15620657.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9BZL1 (Human Ubiquitin-like protein 5) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q9EPV8 (Mouse Ubiquitin-like protein 5) at the PDBe-KB.