UBE2J1

Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.[5][6]

UBE2J1
Identifiers
Aliases	UBE2J1, HSPC153, HSPC205, HSU93243, NCUBE-1, NCUBE1, UBC6, Ubc6p, CGI-76, UBC6E, ubiquitin conjugating enzyme E2 J1
External IDs	OMIM: 616175 MGI: 1926245 HomoloGene: 41090 GeneCards: UBE2J1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,326,625 bp[1] End 89,352,722 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 33,031,416 bp[2] End 33,052,363 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • ATP binding • ubiquitin protein ligase binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • ubiquitin conjugating enzyme activity Cellular component • cytoplasm • membrane • integral component of membrane • endoplasmic reticulum membrane • endoplasmic reticulum Biological process • regulation of tumor necrosis factor biosynthetic process • protein N-linked glycosylation via asparagine • protein ubiquitination • ubiquitin-dependent ERAD pathway • spermatid development • negative regulation of retrograde protein transport, ER to cytosol Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51465	56228
Ensembl	ENSG00000198833	ENSMUSG00000028277
UniProt	Q9Y385	Q9JJZ4
RefSeq (mRNA)	NM_016021	NM_019586 NM_001355494
RefSeq (protein)	NP_057105	NP_062532 NP_001342423
Location (UCSC)	Chr 6: 89.33 – 89.35 Mb	Chr 4: 33.03 – 33.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000198833 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028277 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lester D, Farquharson C, Russell G, Houston B (Apr 2000). "Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6". Biochem Biophys Res Commun. 269 (2): 474–80. doi:10.1006/bbrc.2000.2302. PMID 10708578.
6. "Entrez Gene: UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Lenk U, Yu H, Walter J, et al. (2002). "A role for mammalian Ubc6 homologues in ER-associated protein degradation". J. Cell Sci. 115 (Pt 14): 3007–14. PMID 12082160.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wu CJ, Conze DB, Li X, et al. (2005). "TNF-α induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination". EMBO J. 24 (10): 1886–98. doi:10.1038/sj.emboj.7600649. PMC 1142588. PMID 15861135.
• Oh RS, Bai X, Rommens JM (2006). "Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress". J. Biol. Chem. 281 (30): 21480–90. doi:10.1074/jbc.M601843200. PMID 16720581.